| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
|
|
|
|
|||||||||||||
|
|
|||||||||||||||
Department of Paediatrics, John Radcliffe Hospital,
Oxford, OX3 9DU
Correspondence to: Dr Peter Hope.
Accepted 11 December 1996
AIMS
To determine the prevalence of unilateral
neonatal cerebral infarction in infants born at 32 weeks gestation and
above; to describe the clinical course, imaging results, and outcome of neonatal cerebral infarction; and to investigate possible aetiology.
METHODSTwelve cases of unilateral neonatal
cerebral infarction were identified from neonatal unit records for the
years 1987-93. Each case was matched with two controls.
RESULTSAll cases of neonatal cerebral infarction
occurred in full term infants. The prevalence was around 1 in 4000, and
neonatal cerebral infarction was found in 12% of infants presenting
with neonatal seizures. Cerebral ultrasound scans failed to demonstrate lesions seen by computed tomography in nine of 12 cases. Cases were
more likely than controls to require assisted ventilation for
resuscitation at birth (OR 7.0, 95% confidence interval 1.04-53.5), but Apgar scores at 5 minutes were no different. One infant with neonatal cerebral infarction developed a hemiparesis, the other 11 had
normal motor development when assessed at 11-60 (median 33) months.
None had overt cognitive deficits or persisting seizure disorder.
CONCLUSIONSNeonatal cerebral infarction is
a relatively common cause of neonatal seizures, but the aetiology
remains unclear. Parents need to be made aware of possible neurological
sequelae, but most cases in this series had a normal outcome.
This article has been cited by other articles:
|
|
 |
|
  E. S. Roach, M. R. Golomb, R. Adams, J. Biller, S. Daniels, G. deVeber, D. Ferriero, B. V. Jones, F. J. Kirkham, R. M. Scott, et al. Management of Stroke in Infants and Children: A Scientific Statement From a Special Writing Group of the American Heart Association Stroke Council and the Council on Cardiovascular Disease in the Young Stroke, September 1, 2008; 39(9): 2644 - 2691. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. C. Fitzgerald, L. S. Williams, B. P. Garg, and M. R. Golomb Epilepsy in Children With Delayed Presentation of Perinatal Stroke J Child Neurol, November 1, 2007; 22(11): 1274 - 1280. [Abstract] [PDF]
|
|
|
|
|
|
R. Laugesaar, A. Kolk, T. Tomberg, T. Metsvaht, M. Lintrop, H. Varendi, and T. Talvik Acutely and Retrospectively Diagnosed Perinatal Stroke: A Population-Based Study Stroke, August 1, 2007; 38(8): 2234 - 2240. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J.N.L. Benders, F. Groenendaal, C. S.P.M. Uiterwaal, P. G.J. Nikkels, H. W. Bruinse, R. A.J. Nievelstein, and L. S. de Vries Maternal and Infant Characteristics Associated With Perinatal Arterial Stroke in the Preterm Infant Stroke, June 1, 2007; 38(6): 1759 - 1765. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Bednarek, P. Morville, G. Delebarre, A. Akhavi, and C. Sommer Necrotic Skin Lesions and Cerebral Infarction in the Newborn: Two Case Reports J Child Neurol, March 1, 2007; 22(3): 354 - 357. [Abstract] [PDF]
|
|
|
|
 |
|
 L M Beattie, S J Butler, and D E Goudie Pathways of neonatal stroke and subclavian steal syndrome. Arch. Dis. Child. Fetal Neonatal Ed., May 1, 2006; 91(3): F204 - F207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F Cowan, E Mercuri, F Groenendaal, L Bassi, D Ricci, M Rutherford, and L de Vries Does cranial ultrasound imaging identify arterial cerebral infarction in term neonates? Arch. Dis. Child. Fetal Neonatal Ed., May 1, 2005; 90(3): F252 - f256. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Lee, L. A. Croen, K. H. Backstrand, C. K. Yoshida, L. H. Henning, C. Lindan, D. M. Ferriero, H. J. Fullerton, A. J. Barkovich, and Y. W. Wu Maternal and Infant Characteristics Associated With Perinatal Arterial Stroke in the Infant JAMA, February 9, 2005; 293(6): 723 - 729. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Boardman, V. Ganesan, M. A. Rutherford, D. E. Saunders, E. Mercuri, and F. Cowan Magnetic Resonance Image Correlates of Hemiparesis After Neonatal and Childhood Middle Cerebral Artery Stroke Pediatrics, February 1, 2005; 115(2): 321 - 326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. W. Wu, W. M. March, L. A. Croen, J. K. Grether, G. J. Escobar, and T. B. Newman Perinatal Stroke in Children With Motor Impairment: A Population-Based Study Pediatrics, September 1, 2004; 114(3): 612 - 619. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Monagle, A. Chan, P. Massicotte, E. Chalmers, and A. D. Michelson Antithrombotic Therapy in Children*: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy Chest, September 1, 2004; 126(3_suppl): 645S - 687S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E Mercuri, S Anker, A Guzzetta, A Barnett, L Haataja, M Rutherford, F Cowan, L Dubowitz, O Braddick, and J Atkinson Neonatal cerebral infarction and visual function at school age Arch. Dis. Child. Fetal Neonatal Ed., November 1, 2003; 88(6): F487 - 491. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M J Parker, G I Joubert, and S D Levin Portal vein thrombosis causing neonatal cerebral infarction Arch. Dis. Child. Fetal Neonatal Ed., September 1, 2002; 87(2): F125 - 127. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Andrew, P. Monagle, G. deVeber, and A. K.C. Chan Thromboembolic Disease and Antithrombotic Therapy in Newborns Hematology, January 1, 2001; 2001(1): 358 - 374. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Govaert, E. Matthys, A. Zecic, F. Roelens, A. Oostra, and B. Vanzieleghem Perinatal cortical infarction within middle cerebral artery trunks Arch. Dis. Child. Fetal Neonatal Ed., January 1, 2000; 82(1): 59F - 63. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
| ARCH DIS CHILD | FETAL NEONATAL ED | ED PRACTICE |
