Arch Dis Child Fetal Neonatal Ed 1997;76:F163-F167 ( May )

Neonatal symptomatic thromboembolism in Germany: two year survey

Ulrike Nowak-Göttl,^a Rüdiger von Kries,^b Ullrich Göbel^c

^a Departments of Paediatrics, University Hospital of Münster, ^b University Hospital of Munich, ^c University Hospital of Düsseldorf

Correspondence to: Dr Ulrike Nowak-Göttl Department of Paediatric Haematology/Oncology, University Children's Hospital, Westfälische Wilhelms-University, Albert-Schweitzer- Str. 33, D-48149 Münster, Germany.

Accepted 2 January 1997

AIMSTo determine the incidence of neonatal thromboembolism in Germany.
METHODSDiagnostic imaging techniques, therapeutic modalities, and short term outcome were evaluated in a prospective nationwide two year case registry study.
RESULTSThe reported incidence of symptomatic neonatal thromboembolism, diagnosed in most cases with Doppler ultrasonography, was 5.1 per 100 000 births, with a total of 79 cases registered: renal venous thrombosis (n=35); venous thrombosis (n=25); and arterial vascular occlusion (n=19). Fifty seven of 79 thromboses were associated with additional risk factors (central line n=25, asphyxia n=13, septicaemia n=11, dehydration n=6, maternal diabetes n=2, cardiac disease n=1). Inherited thrombophilia was also diagnosed in seven out of 35 cases investigated. Twenty three children received supportive treatment: 42 received heparin and in 13 neonates thrombolytic agents were administered. Most neonates (91%) survived; seven died.
CONCLUSIONControlled multicentre studies are needed to obtain more information on treatment efficacy.

Keywords: thromboembolism; Doppler ultrasonography; heparin; thrombolytic agents; Germany

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© 1997 by Archives of Disease in Childhood
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