Arch Dis Child Fetal Neonatal Ed 1997;76:F174-F178 ( May )

Randomised trial of dopamine compared with hydrocortisone for the treatment of hypotensive very low birthweight infants

David Bourchier, Philip J Weston

Newborn Intensive Care, Waikato Hospital, Private Bag 3200, Hamilton, New Zealand

Correspondence to: Dr Bourchier.

Accepted 2 January 1997

AIMTo compare the efficacy of hydrocortisone with dopamine for the treatment of hypotensive, very low birthweight (VLBW) infants.
METHODSForty infants were randomly allocated to receive either hydrocortisone (n=21) or dopamine (n=19).
RESULTSAll 19 infants randomised to dopamine responded; 17 of 21 (81%) did so in the hydrocortisone group. Three of the four non-responders in the hydrocortisone group had clinically significant left to right ductal shunting. The incidence of bronchopulmonary dysplasia, retinopathy of prematurity, intraventricular haemorrhage, necrotising enterocolitis, symptomatic patent ductus arteriosus, hyperglycaemia, sepsis (bacterial or fungal) or survival did not differ between groups. The adrenocorticotrophic hormone (ACTH) stimulated plasma cortisol activity, either before or after treatment, did not differ between the two groups of infants. Although a significant difference in efficacy between dopamine and hydrocortisone was not noted (P = 0.108), there were four treatment failures in the hydrocortisone group, compared with none in the dopamine group.
CONCLUSIONBoth hydrocortisone and dopamine are effective treatments for hypotension in very low birthweight infants.

Keywords: hydrocortisone; dopamine; hypotension; very low birthweight; plasma cortisol

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© 1997 by Archives of Disease in Childhood
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