Arch. Dis. Child

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER
[Advanced]

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this link to a friend
Right arrow Similar articles in ADC Online
Right arrow Similar articles in PubMed
Right arrow Add article to my folders
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bourchier, D.
Right arrow Articles by Weston, P. J
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bourchier, D.
Right arrow Articles by Weston, P. J
Arch Dis Child Fetal Neonatal Ed 1997;76:F174-F178 ( May )

Randomised trial of dopamine compared with hydrocortisone for the treatment of hypotensive very low birthweight infants

David Bourchier, Philip J Weston

Newborn Intensive Care, Waikato Hospital, Private Bag 3200, Hamilton, New Zealand

Correspondence to: Dr Bourchier.

Accepted 2 January 1997

AIM---To compare the efficacy of hydrocortisone with dopamine for the treatment of hypotensive, very low birthweight (VLBW) infants.
METHODS---Forty infants were randomly allocated to receive either hydrocortisone (n=21) or dopamine (n=19).
RESULTS---All 19 infants randomised to dopamine responded; 17 of 21 (81%) did so in the hydrocortisone group. Three of the four non-responders in the hydrocortisone group had clinically significant left to right ductal shunting. The incidence of bronchopulmonary dysplasia, retinopathy of prematurity, intraventricular haemorrhage, necrotising enterocolitis, symptomatic patent ductus arteriosus, hyperglycaemia, sepsis (bacterial or fungal) or survival did not differ between groups. The adrenocorticotrophic hormone (ACTH) stimulated plasma cortisol activity, either before or after treatment, did not differ between the two groups of infants. Although a significant difference in efficacy between dopamine and hydrocortisone was not noted (P = 0.108), there were four treatment failures in the hydrocortisone group, compared with none in the dopamine group.
CONCLUSION---Both hydrocortisone and dopamine are effective treatments for hypotension in very low birthweight infants.

Keywords: hydrocortisone; dopamine; hypotension; very low birthweight; plasma cortisol


© 1997 by Archives of Disease in Childhood



This article has been cited by other articles:


Home page
NeoReviewsHome page
A. M. Weindling and N. V. Subhedar
The Definition of Hypotension in Very Low-birthweight Infants During the Immediate Neonatal Period
NeoReviews, January 1, 2007; 8(1): e32 - e43.
[Abstract] [Full Text] [PDF]


Home page
PediatricsHome page
N. N. Finer, R. J. Powers, C.-h. S. Ou, D. Durand, D. Wirtschafter, J. B. Gould, and for the California Perinatal Quality Care Collabor
Prospective Evaluation of Postnatal Steroid Administration: A 1-Year Experience From the California Perinatal Quality Care Collaborative
Pediatrics, March 1, 2006; 117(3): 704 - 713.
[Abstract] [Full Text] [PDF]


Home page
PediatricsHome page
P. C. Ng, C. H. Lee, F. L. Bnur, I. H.S. Chan, A. W.Y. Lee, E. Wong, H. B. Chan, C. W.K. Lam, B. S.C. Lee, and T. F. Fok
A Double-Blind, Randomized, Controlled Study of a "Stress Dose" of Hydrocortisone for Rescue Treatment of Refractory Hypotension in Preterm Infants
Pediatrics, February 1, 2006; 117(2): 367 - 375.
[Abstract] [Full Text] [PDF]


Home page
NeoReviewsHome page
D. Osborn, N. Evans, and M. Kluckow
Diagnosis and Treatment of Low Systemic Blood Flow in Preterm Infants
NeoReviews, March 1, 2004; 5(3): e109 - 121.
[Full Text] [PDF]


Home page
Arch. Dis. Child. Fetal Neonatal Ed.Home page
P C Ng, C H Lee, C W K Lam, K C Ma, T F Fok, I H S Chan, and E Wong
Transient adrenocortical insufficiency of prematurity and systemic hypotension in very low birthweight infants
Arch. Dis. Child. Fetal Neonatal Ed., March 1, 2004; 89(2): F119 - F126.
[Abstract] [Full Text] [PDF]


Home page
Arch. Dis. Child. Fetal Neonatal Ed.Home page
D A Osborn, N Evans, and M Kluckow
Clinical detection of low upper body blood flow in very premature infants using blood pressure, capillary refill time, and central-peripheral temperature difference
Arch. Dis. Child. Fetal Neonatal Ed., March 1, 2004; 89(2): F168 - F173.
[Abstract] [Full Text] [PDF]


Home page
Arch. Dis. Child. Fetal Neonatal Ed.Home page
S J Dasgupta and A B Gill
Hypotension in the very low birthweight infant: the old, the new, and the uncertain
Arch. Dis. Child. Fetal Neonatal Ed., November 1, 2003; 88(6): F450 - 454.
[Abstract] [Full Text] [PDF]


Home page
Arch. Dis. Child. Fetal Neonatal Ed.Home page
M. BURMESTER, C. PIERCE, and A. PETROS
Disseminated candidiasis after steroid treatment for early neonatal hypotension
Arch. Dis. Child. Fetal Neonatal Ed., November 1, 2001; 85(3): F225b - 225.
[Full Text] [PDF]


Home page
Arch. Dis. Child.Home page
B. Phillips
Towards evidence based medicine for paediatricians
Arch. Dis. Child., September 1, 2001; 85(3): 252 - 255.
[Full Text] [PDF]


Home page
Arch. Dis. Child. Fetal Neonatal Ed.Home page
M. Heckmann, S. A Wudy, D. Haack, and F. Pohlandt
Reference range for serum cortisol in well preterm infants
Arch. Dis. Child. Fetal Neonatal Ed., November 1, 1999; 81(3): 171F - 174.
[Abstract] [Full Text]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER
ARCH DIS CHILD FETAL NEONATAL ED ED PRACTICE
Terms and conditions relating to subscriptions purchased online  ¦  Website terms and conditions  ¦  Privacy policy
Copyright © 1997 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health