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Archives of Disease in Childhood - Fetal and Neonatal Edition 1997;76:F179-F184; doi:10.1136/fn.76.3.F179
Copyright © 1997 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health.
Arch Dis Child Fetal Neonatal Ed 1997;76:F179-F184 ( May )

Treatment of patent ductus arteriosus with ibuprofen

Bart Van Overmeire,a Ingrid Follens,a Suzanne Hartmann,a Wouter L Creten,b Karel J Van Ackera

a Department of Paediatrics, Division of Neonatology, University Hospital of Antwerp, Wilrijkstraat 10, B 2650 Edegem, Antwerp, Belgium, b Department of Biomedical Physics

Correspondence to: Dr Bart Van Overmeire.

Accepted 14 January 1997

AIM---To evaluate the efficiency and side effects of ibuprofen for the early treatment of patent ductus arteriosus (PDA)and compare it with indomethacin.
METHODS---Forty preterm infants with gestational ages of less than 33 weeks, with respiratory distress syndrome (RDS) and echocardiographically confirmed PDA, were randomly assigned at days 2 to 3 of life to receive either intravenous indomethacin 3 × 0.2 mg/kg at 12 hour intervals or intravenous ibuprofen 1 × 10 mg/kg, followed by 5 mg/kg 24 and 48 hours later.
RESULTS---PDA closed in 15 of 20 patients from the indomethacin group (75%) and in 16 of 20 (80%) from the ibuprofen group. Seven patients (three indomethacin, four ibuprofen) required a second treatment with indomethacin and in five (three in the indomethacin group and two in the ibuprofen group) the duct was ultimately ligated. Ibuprofen patients had a better urinary output and showed no increase in serum creatinine concentrations compared with the indomethacin group. Ibuprofen was not associated with any other side effect.
CONCLUSIONS---Ibuprofen treatment seems to be as efficient as indomethacin in closing PDA on the third day of life in preterm infants with respiratory distress syndrome and seems to have fewer renal side effects.

Keywords: patent ductus arteriosus; respiratory distress syndrome; ibuprofen; indomethacin; Doppler echocardiography


© 1997 by Archives of Disease in Childhood

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This article has been cited by other articles:

  • Vanhaesebrouck, S., Zonnenberg, I., Vandervoort, P., Bruneel, E., Van Hoestenberghe, M.-R., Theyskens, C. (2007). Conservative treatment for patent ductus arteriosus in the preterm. Arch. Dis. Child. Fetal Neonatal Ed. 92: F244-F247 [Abstract] [Full Text]  

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