Treatment of patent ductus arteriosus with ibuprofen
a Department of
Paediatrics, Division of Neonatology, University Hospital of Antwerp,
Wilrijkstraat 10, B 2650 Edegem, Antwerp, Belgium, b Department of Biomedical Physics
Correspondence to: Dr Bart Van Overmeire.
Accepted 14 January 1997
AIM
To evaluate the efficiency and side effects of
ibuprofen for the early treatment of patent ductus arteriosus (PDA)and
compare it with indomethacin.
METHODSForty preterm infants with gestational
ages of less than 33 weeks, with respiratory distress syndrome (RDS)
and echocardiographically confirmed PDA, were randomly assigned at days
2 to 3 of life to receive either intravenous indomethacin 3 × 0.2 mg/kg at 12 hour intervals or intravenous ibuprofen 1 × 10 mg/kg,
followed by 5 mg/kg 24 and 48 hours later.
RESULTSPDA closed in 15 of 20 patients from the
indomethacin group (75%) and in 16 of 20 (80%) from the ibuprofen
group. Seven patients (three indomethacin, four ibuprofen) required a
second treatment with indomethacin and in five (three in the
indomethacin group and two in the ibuprofen group) the duct was
ultimately ligated. Ibuprofen patients had a better urinary output and
showed no increase in serum creatinine concentrations compared with the
indomethacin group. Ibuprofen was not associated with any other side effect.
CONCLUSIONSIbuprofen treatment seems to be as
efficient as indomethacin in closing PDA on the third day of life in
preterm infants with respiratory distress syndrome and seems to have
fewer renal side effects.
© 1997 by Archives of Disease in Childhood
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