Arch. Dis. Child

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER
[Advanced]

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this link to a friend
Right arrow Similar articles in ADC Online
Right arrow Similar articles in PubMed
Right arrow Add article to my folders
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Van Overmeire, B.
Right arrow Articles by Van Acker, K. J
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Van Overmeire, B.
Right arrow Articles by Van Acker, K. J
Arch Dis Child Fetal Neonatal Ed 1997;76:F179-F184 ( May )

Treatment of patent ductus arteriosus with ibuprofen

Bart Van Overmeire,a Ingrid Follens,a Suzanne Hartmann,a Wouter L Creten,b Karel J Van Ackera

a Department of Paediatrics, Division of Neonatology, University Hospital of Antwerp, Wilrijkstraat 10, B 2650 Edegem, Antwerp, Belgium, b Department of Biomedical Physics

Correspondence to: Dr Bart Van Overmeire.

Accepted 14 January 1997

AIM---To evaluate the efficiency and side effects of ibuprofen for the early treatment of patent ductus arteriosus (PDA)and compare it with indomethacin.
METHODS---Forty preterm infants with gestational ages of less than 33 weeks, with respiratory distress syndrome (RDS) and echocardiographically confirmed PDA, were randomly assigned at days 2 to 3 of life to receive either intravenous indomethacin 3 × 0.2 mg/kg at 12 hour intervals or intravenous ibuprofen 1 × 10 mg/kg, followed by 5 mg/kg 24 and 48 hours later.
RESULTS---PDA closed in 15 of 20 patients from the indomethacin group (75%) and in 16 of 20 (80%) from the ibuprofen group. Seven patients (three indomethacin, four ibuprofen) required a second treatment with indomethacin and in five (three in the indomethacin group and two in the ibuprofen group) the duct was ultimately ligated. Ibuprofen patients had a better urinary output and showed no increase in serum creatinine concentrations compared with the indomethacin group. Ibuprofen was not associated with any other side effect.
CONCLUSIONS---Ibuprofen treatment seems to be as efficient as indomethacin in closing PDA on the third day of life in preterm infants with respiratory distress syndrome and seems to have fewer renal side effects.

Keywords: patent ductus arteriosus; respiratory distress syndrome; ibuprofen; indomethacin; Doppler echocardiography


© 1997 by Archives of Disease in Childhood



This article has been cited by other articles:


Home page
Arch. Dis. Child. Fetal Neonatal Ed.Home page
S. Vanhaesebrouck, I. Zonnenberg, P. Vandervoort, E. Bruneel, M.-R. Van Hoestenberghe, and C. Theyskens
Conservative treatment for patent ductus arteriosus in the preterm
Arch. Dis. Child. Fetal Neonatal Ed., July 1, 2007; 92(4): F244 - F247.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER
ARCH DIS CHILD FETAL NEONATAL ED ED PRACTICE
Terms and conditions relating to subscriptions purchased online  ¦  Website terms and conditions  ¦  Privacy policy
Copyright © 1997 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health