Renal calcification in preterm infants: follow up at 4-5 years
Royal Liverpool Children's Hospital, Alder Hey, Eaton
Road, Liverpool, L12 2AP
Correspondence to: Dr B A Judd.
Accepted 7 January 1997
AIM
To determine the consequences of renal
calcification in preterm infants.
METHODSA cohort of 11 preterm babies was studied
at the age of 4 to 5 years. They had had renal calcification as
neonates. Seventeen matched controls were also studied. Each child had
a renal ultrasound scan, a calcium load test, and a desmopressin test
for renal concentrating ability (RCA). The study group also had
glomerular filtration rate (GFR) estimated, using the height:creatinine
ratio, and tubular phosphate reabsorption, without phosphate load, per
glomerular filtration rate (Tp/GFR) calculated.
RESULTSIn the study group the median GFR was 61 ml/min/1.73m2 (range 46-79 ml/min/1.73m2) and
the median calculated Tp/GFR SD score was 
0.94 (range 2.8- 0.68). Five children out of the study group had ultrasonic evidence of
renal calcification. There was no significant difference between the
two groups in renal size, calciuria, before or after calcium load, or
RCA. Eight children (three patients, five controls) had an abnormal
calcium load test. The RCA of the children in the study and control
groups combined was below that of published values, with a median
calculated SD score 0.71 (95% CI 1.21 to 0.23).
CONCLUSIONSThere was evidence of renal
dysfunction in children who had been born preterm. Renal calcification
detected in the neonatal period does not seem to be a major
predisposing factor for the abnormalities of renal function
subsequently observed in these infants.
© 1997 by Archives of Disease in Childhood
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