Developmental pattern of 3-oxo-
4 bile acids in
neonatal bile acid metabolism
a Department of Paediatrics and Child
Health, Kurume University School of Medicine,
Fukuoka, Japan, b Research Institute of Medical Mass
Spectrometry, c Faculty of Pharmaceutical
Sciences, Health Sciences University of Hokkaido
Correspondence to: Dr Akihiko Kimura, Department of Paediatrics and Child Health, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830, Japan.
Accepted 4
February 1997
AIMS
To investigate whether a fetal pathway of
bile acid synthesis persists in neonates and infants.
METHODS3-oxo-
4 bile acids were
determined qualitatively and quantitatively in the urine, meconium, and
faeces of healthy neonates and infants, using gas chromatography-mass spectrometry.
RESULTSThe mean percentage of
3-oxo-4 bile acids in total bile acids in urine at birth
was significantly higher than that at 3 or 7 days, and at 1 or 3 months
of age. The concentration of this component in meconium was
significantly higher than that in faeces at 7 days and at 1 or 3 months
of age.
CONCLUSIONSThe presence of large amounts of
urinary 3-oxo-4 bile acids may indicate immaturity in
the activity of hepatic 3-oxo-4-steroid 5
-reductase
in the first week of postnatal life. Large amounts of this component in
meconium may be due to the ingestion of amniotic fluid by the fetus
during pregnancy.
4 bile acid;
3-oxo-4-steroid 5-reductase;
meconium;
gas
chromatography-mass spectrometry
© 1997 by Archives of Disease in Childhood
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