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Arch Dis Child Fetal Neonatal Ed 1997;77:F52-F56 ( July )

Developmental pattern of 3-oxo-Delta 4 bile acids in neonatal bile acid metabolism

Toshiro Inoue,a Akihiko Kimura,a Kumiko Aoki,b Masahiko Tohma,c Hirohisa Katoa

a Department of Paediatrics and Child Health, Kurume University School of Medicine, Fukuoka, Japan, b Research Institute of Medical Mass Spectrometry, c Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido

Correspondence to: Dr Akihiko Kimura, Department of Paediatrics and Child Health, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830, Japan.

Accepted 4 February 1997

AIMS---To investigate whether a fetal pathway of bile acid synthesis persists in neonates and infants.
METHODS---3-oxo-Delta 4 bile acids were determined qualitatively and quantitatively in the urine, meconium, and faeces of healthy neonates and infants, using gas chromatography-mass spectrometry.
RESULTS---The mean percentage of 3-oxo-Delta 4 bile acids in total bile acids in urine at birth was significantly higher than that at 3 or 7 days, and at 1 or 3 months of age. The concentration of this component in meconium was significantly higher than that in faeces at 7 days and at 1 or 3 months of age.
CONCLUSIONS---The presence of large amounts of urinary 3-oxo-Delta 4 bile acids may indicate immaturity in the activity of hepatic 3-oxo-Delta 4-steroid 5beta -reductase in the first week of postnatal life. Large amounts of this component in meconium may be due to the ingestion of amniotic fluid by the fetus during pregnancy.

Keywords: ketonic bile acid; 3-oxo-Delta 4 bile acid; 3-oxo-Delta 4-steroid 5beta -reductase; meconium; gas chromatography-mass spectrometry


© 1997 by Archives of Disease in Childhood



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C M P Rodrigues, J J G Marin, and D Brites
Bile acid patterns in meconium are influenced by cholestasis of pregnancy and not altered by ursodeoxycholic acid treatment
Gut, September 1, 1999; 45(3): 446 - 452.
[Abstract] [Full Text] [PDF]




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