Indices of renal tubular function in perinatal asphyxia
a Department of Biochemistry, Princess Margaret
Hospital for Children, GPO Box D184 Perth 6001, Western Australia, b Department of
Neonatology, c Department of
Nephrology
Correspondence to: Dr FR Willis.
Accepted 30
January 1997
Aims
To determine and compare two urinary
indices of renal tubular function,
N-acetyl-glucosaminidase (NAG) and
2-microglobulin (2M), in healthy term
neonates and babies with perinatal asphyxia.
METHODSIn a prospective case-control study using
asphyxiated (n=35) and normal control (n=55) infants, urinary NAG and
2M were assayed at 24-48 hours of life, 4-6 days, and
4-6 weeks.
RESULTSNAG and 2M were
significantly increased at 24-48 hours and 4-6 days in the
asphyxiated infants compared with the controls. Increased NAG values
reflect the degree of perinatal asphyxia more than do
2M. Gentamicin also increased NAG excretion, but to a
lesser extent than did perinatal asphyxia.
CONCLUSIONSNAG (+/- 2M) may be a
useful marker of perinatal asphyxia. Urinary NAG concentrations
correlate with the severity of perinatal asphyxia.
© 1997 by Archives of Disease in Childhood
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