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Arch Dis Child Fetal Neonatal Ed 1997;77:F57-F60 ( July )

Indices of renal tubular function in perinatal asphyxia

Frank Willis,c Julie Summers,a Corrado Minutillo,b Ian Hewittc

a Department of Biochemistry, Princess Margaret Hospital for Children, GPO Box D184 Perth 6001, Western Australia, b Department of Neonatology, c Department of Nephrology

Correspondence to: Dr FR Willis.

Accepted 30 January 1997

Aims---To determine and compare two urinary indices of renal tubular function, N-acetyl-glucosaminidase (NAG) and beta 2-microglobulin (beta 2M), in healthy term neonates and babies with perinatal asphyxia.
METHODS---In a prospective case-control study using asphyxiated (n=35) and normal control (n=55) infants, urinary NAG and beta 2M were assayed at 24-48 hours of life, 4-6 days, and 4-6 weeks.
RESULTS---NAG and beta 2M were significantly increased at 24-48 hours and 4-6 days in the asphyxiated infants compared with the controls. Increased NAG values reflect the degree of perinatal asphyxia more than do beta 2M. Gentamicin also increased NAG excretion, but to a lesser extent than did perinatal asphyxia.
CONCLUSIONS---NAG (+/- beta 2M) may be a useful marker of perinatal asphyxia. Urinary NAG concentrations correlate with the severity of perinatal asphyxia.

Keywords: perinatal asphyxia; renal tubular function; N-acetyl-glucosaminidase

© 1997 by Archives of Disease in Childhood


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