Cisapride reduces neonatal postoperative ileus: randomised placebo controlled trial
a Department of Paediatric Surgery, Children's
Hospital Birmingham, b Institute of Child Health,
University of Birmingham
Correspondence to: Mr Anthony Lander, Department of Paediatric Surgery, Birmingham Children's Hospital, Ladywood Middleway, Ladywood, Birmingham B16 8ET. Email:101366.153{at}compuserve.com
Accepted 18 March 1997
AIM
To assess the efficacy of cisapride in
reducing ileus persisting to the tenth postoperative day after neonatal
abdominal surgery.
METHODSA prospective, randomised, double blind
trial comparing rectal cisapride (l.4-2.3 mg/kg/day) with placebo over
seven days was undertaken in 33 neonates.
RESULTSSeven of 12 (58%) patients receiving
placebo and eight of 11 (73%) receiving cisapride achieved a first
sustained feed during treatment. Of those receiving cisapride, the
first sustained feed occurred at 2.3 days (SEM 0.6) compared with 4.7 days (SEM 0.8) with placebo. By the seventh day the mean daily net
enteral balance was 69 (SEM 18) ml/kg in the cisapride subgroup and 17 (SEM 8) ml/kg for those receiving placebo. Stool was passed on 6.3 (SEM 0.4) treatment days in the cisapride subgroup compared with 4.1 (SEM
1.0) treatment days in the placebo subgroup.
CONCLUSIONCisapride is effective in neonates
with a prolonged ileus after abdominal surgery.
© 1997 by Archives of Disease in Childhood
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DAVIES, M. W
(2000). The use of cisapride in neonates. Arch. Dis. Child. Fetal Neonatal Ed.
83: 74F-74
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