Randomised trial of volume controlled versus time cycled, pressure limited ventilation in preterm infants with respiratory distress syndrome
a Department of Paediatrics (Division of Neonatology),
South Cleveland Hospital, Middlesbrough, Cleveland TS4 3BW, b Department of Radiology, c Department of Pediatrics,
Division of Neonatal-Perinatal Medicine, University of Michigan Medical
Center, Ann Arbor, Michigan, USA
Correspondence to: Dr Sinha.
Accepted 3 June 1997
Fifty preterm infants weighing 1200 g or more with clinical and
radiographic evidence of respiratory distress syndrome, requiring both
mechanical ventilation and exogenous surfactant replacement, were
randomly allocated to receive either volume controlled ventilation or
time cycled, pressure limited ventilation. Tidal volume delivery in
each group was deliberately controlled at 5-8 ml/kg so that the only
difference between the two groups was the ventilatory modality, the
manner in which tidal volume was delivered. The rest of the ventilatory
management and clinical care was done according to protocol. The two
modes of ventilation were compared by determining the time required to
achieve pre-determined success criteria, based on either the
alveolar-arterial oxygen gradient or the mean airway pressure as a
standard against which the speed of weaning could be objectively
assessed. Infants randomised to volume controlled ventilation met
success criteria sooner and had a shorter duration of mechanical
ventilation. These babies also had a significantly lower incidence of
intraventricular haemorrhages and abnormal periventricular
echodensities on ultrasound scans.
Volume controlled ventilation seems to be both safe and effective in
this group of patients.
© 1997 by Archives of Disease in Childhood
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
Grover, A, Field, D
(2008). Volume-targeted ventilation in the neonate: time to change?. Arch. Dis. Child. Fetal Neonatal Ed.
93: F7-F13
[Full Text] -
Claure, N., Bancalari, E.
(2007). New modes of mechanical ventilation in the preterm newborn: evidence of benefit. Arch. Dis. Child. Fetal Neonatal Ed.
92: F508-F512
[Full Text] -
Reyes, Z. C., Claure, N., Tauscher, M. K., D'Ugard, C., Vanbuskirk, S., Bancalari, E.
(2006). Randomized, Controlled Trial Comparing Synchronized Intermittent Mandatory Ventilation and Synchronized Intermittent Mandatory Ventilation Plus Pressure Support in Preterm Infants. Pediatrics
118: 1409-1417
[Abstract] [Full Text] -
Christou, H., Brodsky, D.
(2005). Lung Injury and Bronchopulmonary Dysplasia in Newborn Infants. J Intensive Care Med
20: 76-87
[Abstract] -
Greenough, A
(2002). Update on modalities of mechanical ventilators. Arch. Dis. Child. Fetal Neonatal Ed.
87: F3-6
[Abstract] [Full Text] -
MAMMEL, M. C
(2000). Mechanical ventilation of the newborn. Arch. Dis. Child. Fetal Neonatal Ed.
83: 224F-224
[Full Text] -
Subhedar, N V, Tan, A T, Sweeney, E M, Shaw, N J
(2000). A comparison of indices of respiratory failure in ventilated preterm infants. Arch. Dis. Child. Fetal Neonatal Ed.
83: 97F-100
[Abstract] [Full Text]
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in ADC Online
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
