Iodine and hypothyroidism in neonates with congenital heart disease
a Department of Neonatology, b Department of Pediatric Cardiology, c Department of Pediatric Endocrinology, d Department of Chemical Pathology, e Sheba Medical Center, Sackler School of Medicine,
Tel Aviv University, Israel
Correspondence to: Dr Nehama Linder, Department of Neonatology, Schneider Children's Medical Center, Kaplan street 14, Petach-Tikva 49202, Israel.
Accepted 3 June 1997
AIM
To evaluate the influence of the intravenous
injection of iodine during cardiac catheterisation, and of topical
iodine antiseptics during surgical procedures, on thyroid function in
full term neonates.
METHODSTwenty one full term infants with major
cardiac anomalies who survived for more than a month were studied.
Thyroxine and thyrotropin concentrations were measured (by
radioimmunoassay) before each procedure, 24 hours after the procedure,
and every week thereafter until the age of 1 month or until normal.
Thyroxine values less than 64.4 nmol/l were considered low, while
thyrotropin values greater than 30 mU/l were considered high.
RESULTSThyroid function tests before iodine
exposure were within normal limits in all infants. Following
catheterisation or surgery six infants had raised thyrotropin
concentrations; three had low thyroxine concentrations. Two of those
infants were treated with L-thyroxine.
CONCLUSIONIodine exposure during cardiac
catheterisation or surgery may induce transient hypothyroidism in term infants.
© 1997 by Archives of Disease in Childhood
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Immunology (including allergy)
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