Effects of cisapride on QTc interval in neonates
a Centre Hospitalier Universitaire, 10 Bd
Maréchal de Lattre de Tassigny, 21034 Dijon, Cedex, France
Service de Pédiatrie 2, Hôpital d'Enfants, b Centre Régional de Pharmacovigilance,
Correspondence to: Dr J B Gouyon.
Accepted 11 June 1997
AIM
Prospective survey of the effects of cisapride
on QTc interval in neonates given cisapride.
METHODSQTc interval was determined just before
and 2.9 (0.9) days after outset of the treatment in 49 neonates treated
with cisapride between 1 August 1995 and 29 February 1996.
RESULTSCisapride significantly increased
QTc interval (p = 0.0001), and this was higher when birthweight or
gestational age were lower. The prolongation of QTc interval above the
arbitrary value of 0.450 (n = 7) was clinically asymptomatic and was
significantly more common in the infants born with a gestational age
33 weeks (n = 6).
CONCLUSIONThe findings indicate that cisapride
accumulates in less mature neonates. Further pharmacokinetic studies
are needed.
© 1997 by Archives of Disease in Childhood
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