Cerebral blood flow increases over the first three days of life in extremely preterm neonates
Department of Paediatrics, University College London
Medical School, London
Correspondence to: Dr Judith Meek, Department of Paediatrics, University College London Medical School, The Rayne Institute, University Street, London WC1E 6JJ. Email: J.Meek{at}ucl.ac.uk
Accepted 14 August 1997
AIM
To measure changes in cerebral haemodynamics
over the first three days of life in very preterm infants with normal brains.
METHODSEleven mechanically ventilated infants
(median gestational age 26 weeks) without evidence of major
abnormalities on cranial ultrasound examination were studied. Cerebral
blood flow (CBF) and cerebral blood volume (CBV) were measured using
near infrared spectroscopy at least twice over the first three days of life.
RESULTSCerebral blood flow increased
significantly with time (p=0.02; stepwise linear regression) and this
was independent of mean arterial blood pressure, PaCO2, and haematocrit.
CONCLUSIONThis change is likely to represent a
normal adaptive response of the cerebral circulation to postnatal life.
© 1998 by Archives of Disease in Childhood
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