Antibodies to varicella zoster virus in the cerebrospinal fluid of neonates with seizures
a Department of Neuropediatrics , North Karelia Central
Hospital, Ioensu, Finland, b Haartman
Institute, Department of Virology, University of Helsinki, c Department of Clinical
Chemistry, University Central Hospital, Helsinki, Finland
Correspondence to: Dr Kirsi Mustonen, Department of Neuropediatrics, North Karelia Central Hospital, 80210 Joensuu, Finland.
Accepted 31 July 1997
Four neonates with convulsions had IgG antibodies in their
cerebrospinal fluid (CSF) to varicella zoster virus (VZV). These antibodies were found in the sera of two of these patients after the
age of 6 months. Antibodies to 16 different microbes were studied from
the serum and CSF of 201 neonates with neurological problems. The
presence of DNA specific to HSV-1, HSV-2, and VZV in the CSF was also
investigated using the polymerase chain reaction (PCR). Antibodies to
VZV were detected in the CSF of four neonates. Antibody indices
suggested production of VZV specific antibodies in the central nervous
system. These findings suggest that intrathecal production of
antibodies to VZV can appear in neonates with neurological problems,
which suggests that intrauterine VZV infection can be acquired without
cutaneous symptoms in the mother.
© 1998 by Archives of Disease in Childhood
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