In vitro effect of dexamethasone phosphate on hematopoietic progenitor cells in preterm infants
Department of Paediatrics, Division of Neonatology,
University of Florida College of Medicine, P O Box
100296 Gainesville, FL, USA
Correspondence to: Dr Yai Li.
Accepted 10 July
1997
The in vitro effect of dexamethasone on the clonal growth of
haematopoietic progenitors in preterm infants was investigated. Concentrations of 106M to 109M were associated
with a dose dependent inhibition of colony formation, with the most
clinically important effects seen on the earliest erythroid and
granulocyte-macrophage colonies. Because of the potential clinical
implications of these observations, studies are needed to determine the
effects of dexamethasone on haematopoiesis in preterm infants.
© 1998 by Archives of Disease in Childhood
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