Soluble L-selectin concentration in bronchoalveolar lavage fluid obtained from infants who develop chronic lung disease of prematurity
a Department of Paediatrics, Hammersmith Hospital, London, b Department of
Respiratory Medicine, Imperial College School of Medicine at St Mary's
Hospital, London, c Department of Infectious
Diseases, Institute of Child Health, London
Correspondence to: Dr Sailesh Kotecha Department of Child Health University of Leicester Leicester LE2 7LX.
Accepted 26 September
1997
AIMS
To explore the changes in neutrophil adhesion
molecule expression and release into bronchoalveolar lavage fluid (BAL)
obtained from infants who developed chronic lung disease (CLD).
METHODSBAL fluid was obtained from 37 infants: 18 (median gestation 26 weeks, birthweight 835 g) who developed CLD, 12 (29 weeks, 1345 g) with respiratory distress syndrome (RDS) and seven
control infants (33 weeks, 2190 g).
RESULTSSoluble L-selectin (sL-selectin) in BAL
fluid from the CLD and non-CLD groups was similar immediately after
birth, but in infants who subsequently developed CLD, sL-selectin
remained persistently increased (at day 7: CLD 42.6 vs RDS
6.0 ng/ml, p<0.05; CLD vs controls 1.5 ng/ml; p<0.05).
CD11b/CD18 expression on neutrophils obtained by BAL increased with
time to reach a maximum at 17 days of age in infants who developed CLD.
CONCLUSIONSThese results suggest that leucocyte
traffic persists in infants who develop CLD and may have an important
part to play in the pathogenesis of CLD.
© 1998 by Archives of Disease in Childhood
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