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Arch Dis Child Fetal Neonatal Ed 1998;79:F61-F63 ( July )

Nasal high frequency ventilation in neonates with moderate respiratory insufficiency

Mark van der Hoeven, Erik Brouwer, Carlos E Blanco

Department of Neonatology, Academic Hospital Maastricht, P Debyelaan 25 PO Box 5800 6202 AZ Maastricht, The Netherlands.

Correspondence to: Dr Mark van der Hoeven. Email: MVH{at}SKIN.AZM.NL


Accepted 14 January 1998

AIM---To investigate the efficacy of nasal high frequency ventilation (nHFV) in newborn infants with moderate respiratory insufficiency.
METHOD---Twenty one preterm and term neonates were treated with nHFV for respiratory insufficiency. Criteria for starting nHFV were: deterioration on nasal CPAP expressed by a median pH of 7.24 and pCO2 of 8.3 kPa, or increasing FIO2. nHFV was delivered using the Infant Star ventilator. Ventilator setting amplitude was 35 cm H2O; mean airway pressure 7 cm H2O; and frequency 10 Hz.
RESULTS---pCO2 decreased significantly from 8.3 kPa to 7.2 kPa after nHFV was started. In five patients nHFV was discontinued after a median period of 61/2 hours due to CO2 retention and high oxygen need, and endotracheal mechanical ventilation was started.
CONCLUSIONS---nHFV can reduce pCO2 in neonates with moderate respiratory insufficiency and, therefore, could be used to decrease the need for endotracheal mechanical ventilation.

Keywords: nasal high frequency ventilation; idiopathic respiratory distress syndrome

© 1998 by Archives of Disease in Childhood


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