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Arch Dis Child Fetal Neonatal Ed 1998;79:F70-F72 ( July )

Neonatal transient hypothyroidism: aetiological study

G Weber,a M C Vigone,a A Rapa,b G Bona,b G Chiumelloa, on behalf of the Italian Collaborative Study on Transient Hypothyroidism

a Department of Paediatrics, Scientific Institute H San Raffaele University of Milan, b Department of Paediatrics Ospedale Maggiore Novara University of Torino

Correspondence to: Dr Giovanna Weber Clinica Pediatrica III H San Raffaele Via Olgettina 60 20132 Milano Italy.


Accepted 14 January 1998

AIMS---To define the aetiology of neonatal transient hypothyroidism (NTH) and recommend preventive measures.
METHODS---Maternal and perinatal clinical data on the use of antiseptics, drugs, and contrast agents containing iodine were collected from 40 subjects. Thyroid stimulating hormone (TSH), free thyroxine (FT4), thyroxine (T4), thyroglobulin (TG), TSH receptor antibodies, thyroid peroxidase antibodies and urinary iodine were measured in random neonatal samples. In the mothers with known or suspected thyroid disorders, TSH, FT4, TSH receptor antibodies and thyroid peroxidase antibodies were also measured.
RESULTS---The NTH aetiology was identified in 85% of cases. More than 50% of the babies with transient hypothyroidism had been exposed to iodine; maternal transfer of antibodies had occurred in a third of them.
CONCLUSIONS---It is suggested that the practice of using iodine containing disinfectants should be withdrawn, and chlorhexidine substituted instead; that pregnant women should be advised of the adverse effects of using iodine products; and that thyroid function should be monitored whenever iodine is used.

Keywords: transient hypothyroidism; screening; iodine; thyroid antibody

© 1998 by Archives of Disease in Childhood


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