Neonatal transient hypothyroidism: aetiological study
a Department of Paediatrics,
Scientific Institute H San Raffaele
University of Milan, b Department
of Paediatrics Ospedale Maggiore
Novara University of
Torino
Correspondence to: Dr Giovanna Weber Clinica Pediatrica III H San Raffaele Via Olgettina 60 20132 Milano Italy.
Accepted 14 January
1998
AIMS
To define the
aetiology of neonatal transient hypothyroidism (NTH) and recommend
preventive measures.
METHODSMaternal and
perinatal clinical data on the use of antiseptics, drugs, and contrast
agents containing iodine were collected from 40 subjects. Thyroid
stimulating hormone (TSH), free thyroxine (FT4), thyroxine (T4),
thyroglobulin (TG), TSH receptor antibodies, thyroid peroxidase
antibodies and urinary iodine were measured in random neonatal samples.
In the mothers with known or suspected thyroid disorders, TSH, FT4, TSH
receptor antibodies and thyroid peroxidase antibodies were also measured.
RESULTSThe NTH
aetiology was identified in 85% of cases. More than 50% of the babies
with transient hypothyroidism had been exposed to iodine; maternal
transfer of antibodies had occurred in a third of them.
CONCLUSIONSIt is
suggested that the practice of using iodine containing disinfectants
should be withdrawn, and chlorhexidine substituted instead; that
pregnant women should be advised of the adverse effects of using iodine
products; and that thyroid function should be monitored whenever iodine
is used.
© 1998 by Archives of Disease in Childhood
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