Neurobehaviour of school age children born to diabetic mothers
a Laboratory of Teratology, Department of
Anatomy and Cell Biology, Hebrew University,
Jerusalem, Israel, b Department of Psychology, c School
of Public Health, d Sheba Medical Center,
Tel Aviv University, Israel
Correspondence to: Dr Asher Ornoy, The Hebrew University Hadassah Medical School Jerusalem PO Box 12272, Jerusalem 91120, Israel.
Accepted 11 March 1998
AIM
To study the neurobehavioural
effects that diabetes during pregnancy might have on children by
school age.
METHODSThe neurobehavioural function of 57 school
age children born to 48, well controlled diabetic mothers
was compared with 57 control children matched for age, birth order, and
parental socioeconomic status, using several cognitive, behavioural,
sensory and motor neurological tests.
RESULTSThe IQ scores of the index group children
were similar to those of control children (117.7±13.4 vs
118.5±10.1). There were no differences between the groups in various
sensory motor functions. However, the index group children performed
less well than the controls on indices of fine and gross motor
functions, as observed on the Bruininks-Oseretzky test of motor
proficiency. The scores of children born to diabetic mothers were
higher than controls on the Touwen and Prechtl neurological
examination. They also performed worse in the Pollack tapper test which
is designed to detect minor neurological deficits, inattention, and
hyperactivity. The index children had higher scores on the Conners
abbreviated parent-teacher questionnaire which measures hyperactivity
and inattention. There was a negative correlation between the
performance of the index group children on various neurodevelopmental
and behavioural tests and the severity of hyperglycaemia, as assessed by blood glycosylated haemoglobin and acetonuria.
CONCLUSIONSDiabetes during pregnancy adversely
affects some fine neurological functions in children at school age, but
not their cognitive scores. These effects are not correlated with the
degree of glycaemic control.
© 1998 by Archives of Disease in Childhood
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