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Archives of Disease in Childhood - Fetal and Neonatal Edition 1998;79:F168-F173; doi:10.1136/fn.79.3.F168
Copyright © 1998 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health.
Arch Dis Child Fetal Neonatal Ed 1998;79:F168-F173 ( November )

Compiling a national register of babies born with anophthalmia/microphthalmia in England 1988-94

Araceli Busby,a Helen Dolk,a Richard Collin,b R Barry Jones,b Robin Winterc

a Environmental Epidemiology Unit Department of Public Health and Policy London School of Hygiene and Tropical Medicine Keppel Street London WC1E 7HT, b Moorfields Eye Hospital London, c Institute of Child Health London

Correspondence to: Dr A Busby.


Accepted 5 June 1998

AIM---To describe the prevalence of anophthalmia/microphthalmia in babies born in England 1988-94, as well as their overall survival, and the incidence of associated eye and non-eye malformations; to determine the usefulness of different sources of medical and health service information for establishing a retrospective register of anophthalmia/microphthalmia.
METHODS---Multiple sources for initial (retrospective) case ascertainment were surveyed, followed by questionnaires to clinicians to establish severity, associated malformations, and aetiology for England, 1988-94. The population surveyed was all births in England for this time period (4 570 350 births). Cases included live births, stillbirths, or terminations after prenatal diagnosis of congenital anomaly, with anophthalmia/microphthalmia, with or without other malformations and syndromes. Trisomy 13 was subsequently excluded.
RESULTS---The proportion of cases notified by any one information source was not more than 26% (Office for National Statistics Register 22%, paediatricians 26%, district sources 25%). Sixty nine per cent of cases (51% of severe cases) were notified by only one source. A total of 449 cases were reported, prevalence 1.0 per 10 000 births. The prevalence was stable over time, although the proportion notified by clinicians rose in more recent years. Thirty four per cent of affected babies had mild microphthalmia. Of those with severe anophthalmia/microphthalmia, 51% were bilateral, other eye malformations were present in 72%, non-eye malformations in 65%, and a "known aetiology" was attributed in 22%. Three quarters of those severely affected survived infancy.
CONCLUSIONS---Despite high response rates from the sources of information contacted, the lack of duplication between sources indicates the difficulties of retrospective ascertainment and the need for multiple sources when establishing a register. Anophthalmos/microphthalmos is usually associated with other malformations. Most cases are of unknown aetiology.

Key messages

 bullet One in 10 000 babies born in England has anophthalmia or microphthalmia, one third of whom are mildly affected
 bullet Most babies born with anophthalmia/microphthalmia have additional malformations
 bullet Retrospective case ascertainment for conditions like anophthalmia/microphthalmia poses particular difficulties due to incomplete or inappropriate diagnostic indexing of existing data collection systems
 bullet The ONS Congenital Malformation Scheme is very incomplete in its ascertainment of babies born with anophthalmia/microphthalmia, whether mild or severe
 bullet Multiple sources of case ascertainment are indispensable for establishing a register of a condition such as anophthalmia/microphthalmia



Keywords: congenital malformation; anophthalmia; microphthalmia; register; epidemiology


© 1998 by Archives of Disease in Childhood

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This article has been cited by other articles:

  • Boyd, P A, Armstrong, B, Dolk, H, Botting, B, Pattenden, S, Abramsky, L, Rankin, J, Vrijheid, M, Wellesley, D (2005). Congenital anomaly surveillance in England--ascertainment deficiencies in the national system. BMJ 330: 27- [Abstract] [Full Text]  

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