Long term neurological dysfunction and neonatal hypoglycaemia after diabetic pregnancy
a Department of Paediatrics Örebro Medical
Centre Hospital 701 85 Örebro, Sweden, b Department of Neurophysiology
Uppsala University Hospital, c Children's Habilitation Centre, Örebro Sweden
Correspondence to: Dr Erik Stenninger.
Accepted 1 April 1998
AIM
To determine if children born to mothers with
diabetes mellitus during pregnancy, who subsequently developed neonatal
hypoglycaemia, experienced long term neurological dysfunction.
METHODSThirteen children with, and 15 without,
neonatal hypoglycaemia (blood glucose < 1.5 mmol/l) were randomly
selected from a larger cohort and investigated at the age of 8 years.
They were also compared with 28 age matched healthy controls.
RESULTSChildren with neonatal hypoglycaemia had
significantly more difficulties in a validated screening test for
minimal brain dysfunction than controls and were also more often
reported to be hyperactive, impulsive, and easily distracted. On
psychological assessment, they had a lower total development score than
normoglycaemic children born to diabetic mothers, and control children.
CONCLUSIONSNeonatal hypoglycaemia in
diabetic pregnancy was associated with long term neurological
dysfunction related to minimal brain dysfunction/deficits in attention,
motor control, and perception.
© 1998 by Archives of Disease in Childhood
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