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Neonatal Unit, Simpson Memorial
Maternity Pavilion, Lauriston Place, Edinburgh EH3
9YW
Correspondence to: Dr B Stenson. Email: Stensonb{at}telemedicine.clh.ed.ac.uk
Accepted 13
May 1998
AIM
To determine the effect of erythromycin on the
establishment of enteral feeding in ventilated infants <31 weeks gestation.
METHODS
Erythromycin was randomly allocated as an
antimicrobial treatment for the first 7 days of life in 76 infants: 35 received erythromycin and 41 acted as controls. Feed toleration, time
taken to establish full enteral feeding, vomiting, prescription of
glycerine suppositories and occurrence of necrotising enterocolitis
were recorded.
RESULTS
There were no significant differences between
the groups for any of the outcomes. The infants treated with
erythromycin reached full feeding at a median (quartile) age of 8 (5-12) days compared with 9 (6-14) days for controls.
CONCLUSIONS
Intravenous erythromycin in antimicrobial
doses is unlikely to benefit the introduction of feeding in preterm infants.
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