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Arch Dis Child Fetal Neonatal Ed 1998;79:F212-F214 ( November )

Influence of erythromycin on establishment of feeding in preterm infants: observations from a randomised controlled trial

Ben J Stenson, Linda Middlemist, Andrew J Lyon

Neonatal Unit, Simpson Memorial Maternity Pavilion, Lauriston Place, Edinburgh EH3 9YW

Correspondence to: Dr B Stenson. Email: Stensonb{at}telemedicine.clh.ed.ac.uk


Accepted 13 May 1998

AIM---To determine the effect of erythromycin on the establishment of enteral feeding in ventilated infants <31 weeks gestation.
METHODS---Erythromycin was randomly allocated as an antimicrobial treatment for the first 7 days of life in 76 infants: 35 received erythromycin and 41 acted as controls. Feed toleration, time taken to establish full enteral feeding, vomiting, prescription of glycerine suppositories and occurrence of necrotising enterocolitis were recorded.
RESULTS---There were no significant differences between the groups for any of the outcomes. The infants treated with erythromycin reached full feeding at a median (quartile) age of 8 (5-12) days compared with 9 (6-14) days for controls.
CONCLUSIONS---Intravenous erythromycin in antimicrobial doses is unlikely to benefit the introduction of feeding in preterm infants.

Keywords: erythromycin; motility; motilin


© 1998 by Archives of Disease in Childhood



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