Influence of erythromycin on establishment of feeding in preterm infants: observations from a randomised controlled trial
Neonatal Unit, Simpson Memorial
Maternity Pavilion, Lauriston Place, Edinburgh EH3
9YW
Correspondence to: Dr B Stenson. Email: Stensonb{at}telemedicine.clh.ed.ac.uk
Accepted 13
May 1998
AIM
To determine the effect of erythromycin on the
establishment of enteral feeding in ventilated infants <31 weeks gestation.
METHODSErythromycin was randomly allocated as an
antimicrobial treatment for the first 7 days of life in 76 infants: 35 received erythromycin and 41 acted as controls. Feed toleration, time
taken to establish full enteral feeding, vomiting, prescription of
glycerine suppositories and occurrence of necrotising enterocolitis
were recorded.
RESULTSThere were no significant differences between
the groups for any of the outcomes. The infants treated with
erythromycin reached full feeding at a median (quartile) age of 8 (5-12) days compared with 9 (6-14) days for controls.
CONCLUSIONSIntravenous erythromycin in antimicrobial
doses is unlikely to benefit the introduction of feeding in preterm infants.
© 1998 by Archives of Disease in Childhood
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