Trisomy 21 associated transient neonatal myeloproliferation in the absence of Down's syndrome
Sheffield Children's Hospital, Western Bank,
Sheffield S10 2TH
Correspondence to: Dr M Richards.
Accepted 17 June 1998
Although usually associated with Down's syndrome, transient
neonatal myeloproliferation (TMD) can occur in the absence of a
constitutional trisomy 21. This report describes two such cases, both
of whom had a trisomy 21 restricted to clonal cells. Unlike in previous
such reported cases, spontaneous morphological, cytogenetic, and
molecular remission in both cases was followed by re-emergence, in one
case, of an evolved clone with a more malignant phenotype which
required pharmacological intervention. Awareness that trisomy 21 bearing leukaemia in the neonatal period can be transient even in the
absence of Down's syndrome is important to prevent unnecessary treatment. Equally, such cases require indefinite follow up as a
proportion may have a recurrence which may require treatment.
© 1998 by Archives of Disease in Childhood
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