Measurement of protein flux with positron emission tomography in neonates
Division of Newborn Medicine, Edward Mallinckrodt
Department of Pediatrics, Washington University School of Medicine and
St Louis Children's Hospital, St Louis, Missouri
Correspondence to: Dr Aaron Hamvas, Division of Newborn Medicine, St Louis Children's Hospital, St Louis, MO 63110 USA.
Accepted 14 August 1998
AIM
To determine whether abnormal transvascular
protein flux can be measured with positron emission tomography (PET) in
neonates with respiratory distress syndrome (RDS).
METHODSFourteen infants with normal gas exchange
(non-RDS group) underwent one PET measurement and 12 infants with RDS
(the RDS group) underwent two measurements of protein flux, as
determined by the pulmonary transcapillary escape rate for
68Gallium labelled transferrin (PTCER).
RESULTSThe mean PTCER for the RDS infants (132 ± 39 10-4/min) was significantly greater than that for
infants without RDS (75 ± 27 10-4/min). PTCER did not
change between measurements in the infants with RDS, including five who
received and responded to surfactant replacement between the two scans.
CONCLUSIONSIncreased transvascular
flux of large molecular weight proteins complicates RDS in
preterm infants. PET provides a tool with which to evaluate the
processes that contribute to pulmonary dysfunction in neonates.
© 1999 by Archives of Disease in Childhood
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