Cerebral blood flow during treatment for pulmonary hypertension
Department of Neonatology
Osaka City General Hospital 2-13-22 Miyakojimahondori Miyakojimaku, Osaka 534-0021 Japan
Correspondence to: Dr Satoshi Kusuda. Email: skusuda{at}msic.med.osaka-cu.ac.jp
Accepted 13
July 1998
AIM
To determine if the haemodynamics of systemic
and cerebral circulation are changed during treatment for persistent
pulmonary hypertension of the newborn (PPHN).
METHODSFifteen term newborn piglets with hypoxia
induced pulmonary hypertension were randomly assigned either tolazoline
infusion (Tz), hyperventilation alkalosis (HAT), and inhaled nitric
oxide (iNO). Mean pulmonary arterial pressure (PAP), mean
systemic arterial pressure (SAP), and cerebral blood flow volume (CBF)
were measured.
RESULTSDuring hypoxic breathing, PAP
increased significantly in all groups. After treatment PAP decreased
significantly in all groups, but no significant difference was observed
between groups. SAP decreased significantly only in the Tz group, and
CBF reduced significantly only in the HAT group. On the other hand, iNO
did not change SAP or CBF.
CONCLUSIONInhaled NO might be ideal for the
resolution of pulmonary hypertension.
© 1999 by Archives of Disease in Childhood
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