Outcome of mother to infant acquired GBV-C/HGV infection
a Fourth Paediatric Department,
Università di Milano, Istituto di Scienze
Biomediche Sacco, via GB Grassi 74, 20157 Milano,
Italy, b Institute of Virology University of Milan
Correspondence to: Dr Giovanna Zuin.
Accepted 3 April 1998
Twelve children born to hepatitis C virus antibody GBV-C/HGV
RNA positive mothers who acquired GBV-C/HGV infection by the vertical
or perinatal route were studied. Most (91%) were persistently GBV-C/HGV RNA positive up to 12 months of age. Four out of six cases
who acquired GBV-C/HGV alone had normal alanine amino transferase activities. Long lasting evidence of hepatocellular injury was detected
only in children with GBV-C/HGV and hepatitis C virus and HIV coinfection.
© 1999 by Archives of Disease in Childhood
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