| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
|
|
|
|
|||||||||||||
|
|
|||||||||||||||
Children's
Respiratory Unit, Department of Paediatrics, United
Medical and Dental School, St Thomas's Hospital, London SEl
7EH
Correspondence to: Professor A D Milner.
Accepted 11 July
1998
AIMS
To assess the effects of smoking during
pregnancy on lung mechanics and lung volumes in the immediate neonatal
period, before infants are exposed to passive smoking.
METHODSLung function tests were carried out within
72 hours of delivery in infants born to 100 non-smoking and 189 smoking
mothers. Lung growth was assessed by plethysmography and lung mechanics using the single breath occlusion technique and oesophageal balloon/ pneumotachography. Antenatal maternal serum cotinine values were obtained from 133 mothers.
RESULTSSmoking was associated with a
significant reduction in birthweight (mean 256 g, 95% CI 0.164 to
0.392), and length (mean 1.26 cm, 95% CI 0.48 to 2.00). Lung volume
was not reduced when related to weight. Smoking was associated with a
highly significant reduction in static compliance (Crs).
This effect remained significant after relating Crs to
weight and lung volume. Regression analyses showed that the
Crs association was limited to the boys. Smoking was associated with a small but significant reduction in respiratory system
conductance (Grs) (single breath occlusion technique) and total pulmonary conductance (Gp). These associations were
limited to girls.
CONCLUSIONSSmoking in pregnancy reduces
static compliance in boys and conductance in girls. There was no
evidence that maternal smoking adversely affected fetal lung growth.
|
Key messages
|
This article has been cited by other articles:
|
|
 |
|
  S Broughton, A Roberts, G Fox, E Pollina, M Zuckerman, S Chaudhry, and A Greenough Prospective study of healthcare utilisation and respiratory morbidity due to RSV infection in prematurely born infants Thorax, December 1, 2005; 60(12): 1039 - 1044. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. D. Skorge, T. M. L. Eagan, G. E. Eide, A. Gulsvik, and P. S. Bakke The Adult Incidence of Asthma and Respiratory Symptoms by Passive Smoking In Utero or in Childhood Am. J. Respir. Crit. Care Med., July 1, 2005; 172(1): 61 - 66. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Burguet, M Kaminski, P Truffert, A Menget, L Marpeau, M Voyer, J C Roze, B Escande, G Cambonie, J M Hascoet, et al. Does smoking in pregnancy modify the impact of antenatal steroids on neonatal respiratory distress syndrome? Results of the Epipage study Arch. Dis. Child. Fetal Neonatal Ed., January 1, 2005; 90(1): F41 - F45. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. K. Jaakkola and M. Gissler Maternal Smoking in Pregnancy, Fetal Development, and Childhood Asthma Am J Public Health, January 1, 2004; 94(1): 136 - 140. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Hulskamp, A.-f. Hoo, H. Ljungberg, S. Lum, J. J. Pillow, and J. Stocks Progressive Decline in Plethysmographic Lung Volumes in Infants: Physiology or Technology? Am. J. Respir. Crit. Care Med., October 15, 2003; 168(8): 1003 - 1009. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K Johnson, C Gerada, and A Greenough Treatment of neonatal abstinence syndrome Arch. Dis. Child. Fetal Neonatal Ed., January 1, 2003; 88(1): F2 - 5. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. S. Sekhon, J. A. Keller, B. J. Proskocil, E. L. Martin, and E. R. Spindel Maternal Nicotine Exposure Upregulates Collagen Gene Expression in Fetal Monkey Lung . Association with alpha 7 Nicotinic Acetylcholine Receptors Am. J. Respir. Cell Mol. Biol., January 1, 2002; 26(1): 31 - 41. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. S. SEKHON, J. A. KELLER, N. L. BENOWITZ, and E. R. SPINDEL Prenatal Nicotine Exposure Alters Pulmonary Function in Newborn Rhesus Monkeys Am. J. Respir. Crit. Care Med., September 15, 2001; 164(6): 989 - 994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. DIMITRIOU, A. GREENOUGH, G. F. RAFFERTY, and J. MOXHAM Effect of Maturity on Maximal Transdiaphragmatic Pressure in Infants during Crying Am. J. Respir. Crit. Care Med., August 1, 2001; 164(3): 433 - 436. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hassan, J. Gossage, D. Ingram, S. Lee, and A. D. Milner Volume of activation of the Hering-Breuer inflation reflex in the newborn infant J Appl Physiol, March 1, 2001; 90(3): 763 - 769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P N Le Souëf Paediatric origins of adult lung diseases bullet 4: Tobacco related lung diseases begin in childhood Thorax, December 1, 2000; 55(12): 1063 - 1067. [Full Text]
|
|
|
|
 |
|
 R. J. Witorsch and P. Witorsch Review : Environmental Tobacco Smoke and Respiratory Health in Children: A Critical Review and Analysis of the Literature from 1969 to 19981 Indoor and Built Environment, September 1, 2000; 9(5): 246 - 264. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
| ARCH DIS CHILD | FETAL NEONATAL ED | ED PRACTICE |
Smoking during pregnancy has an adverse effect on
birthweight, length, head and chest circumference