Serum malondialdehyde concentration in babies with hyperbilirubinaemia
ule Yi
it,a
Murat Yurdakök,a
Kamer Kilinç,b
Olcay Oran,a
Gülsen Erdem,a
Gülsevin Tekinalpa
a Department
Of Pediatrics Hacettepe University Hospital
Ankara Turkey, b Department of
Biochemistry
Correspondence to: Dr S Yiit Ziraat Mühendisleri Sitesi 3 / 21 Çankaya 06650 Ankara Turkey.
Accepted 19 October
1998
AIM
To determine lipid
peroxide concentrations in the first 10 days of life.
METHODSMalondialdehyde
concentrations were investigated in neonates with or without
hyperbilirubinaemia during the first 10 days of life.
RESULTSSerum
malondialdehyde concentrations were higher in infants with
hyperbilirubinaemia than in controls. A positive correlation was found
between malondialdehyde and bilirubin concentrations in the study
group. When the study group was categorised according to the presence
of haemolysis, a significant correlation was found between
malondialdehyde and bilirubin concentrations in those infants with
hyperbilirubinaemia due to haemolysis. There was no such correlation in
those without haemolysis.
CONCLUSIONExchange
transfusion rapidly produces variable changes in pro-oxidant and
antioxidant plasma concentrations in neonates, which may be responsible
for free radical metabolism. The fall in malondialdehyde concentration
is probably directly related to its exogenous removal by exchange transfusion.
Keywords: bilirubin; oxygen free radicals; malondialdehyde
© 1999 by Archives of Disease in Childhood
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