Tonometry to estimate intestinal perfusion in newborn piglets
Morag E Campbella, John E Van Aerdea, Po-Yin Cheungb, Damon C Mayesb
a Neonatal
Intensive Care Unit Children's Health Centre
Departments of Pediatrics
University of Alberta
Edmonton Canada, b Department of Obstetrics
Correspondence to: Dr J Van Aerde 3A3.08 Neonatal Intensive Care Unit W MacKenzie Health Sciences Centre University of Alberta Hospitals Edmonton Alberta Canada T6G 2R7. Email: jvanaerd{at}pop.srv.ualberta.ca.
Accepted 12 March 1999
AIM
To determine the
correlation between gastric intramucosal pH and superior mesenteric
artery (SMA) flow in newborn piglets.
METHODSFourteen
newborn piglets were randomly assigned to either a control or to an
epinephrine group which received 0,1,2,4,0 µg/kg/min of epinephrine
for 60 minutes, each dose. Gastric tonometry was performed, SMA flow
was measured, and intramucosal pH and the ratio of tonometer
pCO2 over arterial pCO2 (rCO2) were calculated.
RESULTSIntramucosal
pH decreased over time in both groups, but tended to be lower in the
epinephrine group. With increasing dose of epinephrine, SMA flow
decreased; this in turn increased rCO2 (p = 0.04) with
a tendency to decrease intramucosal pH (p = 0.06).
CONCLUSIONSGastric
tonometry may be useful in human neonates to evaluate gut ischaemia.
Keywords: tonometry; ischemia; inotropes; bowel
© 1999 by Archives of Disease in Childhood
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
Dasgupta, S J, Gill, A B
(2003). Hypotension in the very low birthweight infant: the old, the new, and the uncertain. Arch. Dis. Child. Fetal Neonatal Ed.
88: F450-454
[Abstract] [Full Text]
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in ADC Online
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
