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a Neonatal
Intensive Care Unit Children's Health Centre
Departments of Pediatrics
University of Alberta
Edmonton Canada, b Department of Obstetrics
Correspondence to: Dr J Van Aerde 3A3.08 Neonatal Intensive Care Unit W MacKenzie Health Sciences Centre University of Alberta Hospitals Edmonton Alberta Canada T6G 2R7. Email: jvanaerd{at}pop.srv.ualberta.ca.
Accepted 12 March 1999
AIM
To determine the
correlation between gastric intramucosal pH and superior mesenteric
artery (SMA) flow in newborn piglets.
METHODSFourteen
newborn piglets were randomly assigned to either a control or to an
epinephrine group which received 0,1,2,4,0 µg/kg/min of epinephrine
for 60 minutes, each dose. Gastric tonometry was performed, SMA flow
was measured, and intramucosal pH and the ratio of tonometer
pCO2 over arterial pCO2 (rCO2) were calculated.
RESULTSIntramucosal
pH decreased over time in both groups, but tended to be lower in the
epinephrine group. With increasing dose of epinephrine, SMA flow
decreased; this in turn increased rCO2 (p = 0.04) with
a tendency to decrease intramucosal pH (p = 0.06).
CONCLUSIONSGastric
tonometry may be useful in human neonates to evaluate gut ischaemia.
This article has been cited by other articles:
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  S J Dasgupta and A B Gill Hypotension in the very low birthweight infant: the old, the new, and the uncertain Arch. Dis. Child. Fetal Neonatal Ed., November 1, 2003; 88(6): F450 - 454. [Abstract] [Full Text] [PDF]
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