|
|
||||||||||||||
|
|
|||||||||||||||
Department of Child
Health University of Liverpool
Royal Liverpool Children's Hospital (Alder
Hey) Liverpool L12 2AP
Correspondence to: Dr R Cooke.
Accepted 7
April 1999
AIM
To determine
whether neurological deficits are associated with structural anomalies
of the brain in very low birthweight (VLBW) infants with subsequent
learning disorders but without cerebral palsy, or whether other
factors, such as poor early growth, are responsible.
METHODS
Eighty seven
VLBW infants and eight term controls who had been examined at school
between the ages of 12 and 13 years, had cranial magnetic resonance
imaging (MRI) scans at 15-17 years of age.
RESULTS
Thirty seven
(42.5%) of the VLBW children had abnormalities reported on their scans
(two porencephaly, 28 periventricular leucomalacia, 24 ventricular
dilatation, and 15 thinning of the corpus callosum). No significant
differences in intelligence quotient, motor clumsiness, or frequency of
attention deficit / hyperactivity disorder were observed between those
children with MRI lesions and those with normal scans. Quantitative
measurements showed the VLBW infants had smaller brains, and a
relatively smaller corpus callosum compared with controls. No
association between brain measurements and school performance was
observed among the VLBW infants.
CONCLUSIONS
The
difficulties experienced by VLBW children at school are unlikely to be
the result of perinatal brain injury, but they might to be attributable
to the effects of poor postnatal growth.
This article has been cited by other articles:
![]() |
J. G. Millichap Developmental Outcome of Very Preterm Infants Correlates with Grey and White Matter Abnormalities AAP Grand Rounds, April 1, 2008; 19(4): 44 - 45. [Full Text] [PDF] |
||||
![]() |
M. Allin, C. Nosarti, A. Narberhaus, M. Walshe, S. Frearson, A. Kalpakidou, J. Wyatt, L. Rifkin, and R. Murray Growth of the Corpus Callosum in Adolescents Born Preterm Arch Pediatr Adolesc Med, December 1, 2007; 161(12): 1183 - 1189. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. Kulak, W. Sobaniec, B. Kubas, and J. Walecki Corpus Callosum Size in Children With Spastic Cerebral Palsy: Relationship to Clinical Outcome J Child Neurol, April 1, 2007; 22(4): 371 - 374. [Abstract] [PDF] |
||||
![]() |
N. G. Anderson, I. Laurent, L. J. Woodward, and T. E. Inder Detection of Impaired Growth of the Corpus Callosum in Premature Infants Pediatrics, September 1, 2006; 118(3): 951 - 960. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. J. Counsell, Y. Shen, J. P. Boardman, D. J. Larkman, O. Kapellou, P. Ward, J. M. Allsop, F. M. Cowan, J. V. Hajnal, A. D. Edwards, et al. Axial and Radial Diffusivity in Preterm Infants Who Have Diffuse White Matter Changes on Magnetic Resonance Imaging at Term-Equivalent Age Pediatrics, February 1, 2006; 117(2): 376 - 386. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. G. Anderson, I. Laurent, N. Cook, L. Woodward, and T. E. Inder Growth Rate of Corpus Callosum in Very Premature Infants AJNR Am. J. Neuroradiol., November 1, 2005; 26(10): 2685 - 2690. [Abstract] [Full Text] [PDF] |
||||
![]() |
K J Rademaker, C S P M Uiterwaal, F J A Beek, I C van Haastert, A F Lieftink, F Groenendaal, D E Grobbee, and L S de Vries Neonatal cranial ultrasound versus MRI and neurodevelopmental outcome at school age in children born preterm Arch. Dis. Child. Fetal Neonatal Ed., November 1, 2005; 90(6): F489 - F493. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Rogers, T. B. Fay, M. F. Whitfield, J. Tomlinson, and R. E. Grunau Aerobic Capacity, Strength, Flexibility, and Activity Level in Unimpaired Extremely Low Birth Weight (<=800 g) Survivors at 17 Years of Age Compared With Term-Born Control Subjects Pediatrics, July 1, 2005; 116(1): e58 - e65. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. E. Inder, S. K. Warfield, H. Wang, P. S. Huppi, and J. J. Volpe Abnormal Cerebral Structure Is Present at Term in Premature Infants Pediatrics, February 1, 2005; 115(2): 286 - 294. [Abstract] [Full Text] [PDF] |
||||
![]() |
Follow-up Care of High-Risk Infants Pediatrics, November 1, 2004; 114(5/S1): 1377 - 1397. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Mirmiran, P. D. Barnes, K. Keller, J. C. Constantinou, B. E. Fleisher, S. R. Hintz, and R. L. Ariagno Neonatal Brain Magnetic Resonance Imaging Before Discharge Is Better Than Serial Cranial Ultrasound in Predicting Cerebral Palsy in Very Low Birth Weight Preterm Infants Pediatrics, October 1, 2004; 114(4): 992 - 998. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Nosarti, T. M. Rushe, P. W. R. Woodruff, A. L. Stewart, L. Rifkin, and R. M. Murray Corpus callosum size and very preterm birth: relationship to neuropsychological outcome Brain, September 1, 2004; 127(9): 2080 - 2089. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Fearon, P. O'Connell, S. Frangou, P. Aquino, C. Nosarti, M. Allin, M. Taylor, A. Stewart, L. Rifkin, and R. Murray Brain Volumes in Adult Survivors of Very Low Birth Weight: A Sibling-Controlled Study Pediatrics, August 1, 2004; 114(2): 367 - 371. [Abstract] [Full Text] [PDF] |
||||
![]() |
N Marlow Neurocognitive outcome after very preterm birth Arch. Dis. Child. Fetal Neonatal Ed., May 1, 2004; 89(3): F224 - F228. [Abstract] [Full Text] [PDF] |
||||
![]() |
F O'Brien, S Roth, A Stewart, L Rifkin, T Rushe, and J Wyatt The neurodevelopmental progress of infants less than 33 weeks into adolescence Arch. Dis. Child., March 1, 2004; 89(3): 207 - 211. [Abstract] [Full Text] [PDF] |
||||
![]() |
T M Rushe, C M Temple, L Rifkin, P W R Woodruff, E T Bullmore, A L Stewart, A Simmons, T A Russell, and R M Murray Lateralisation of language function in young adults born very preterm Arch. Dis. Child. Fetal Neonatal Ed., March 1, 2004; 89(2): F112 - F118. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. S. Peterson, A. W. Anderson, R. Ehrenkranz, L. H. Staib, M. Tageldin, E. Colson, J. C. Gore, C. C. Duncan, R. Makuch, and L. R. Ment Regional Brain Volumes and Their Later Neurodevelopmental Correlates in Term and Preterm Infants Pediatrics, May 1, 2003; 111(5): 939 - 948. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. S. Peterson, B. Vohr, M. J. Kane, D. H. Whalen, K. C. Schneider, K. H. Katz, H. Zhang, C. C. Duncan, R. Makuch, J. C. Gore, et al. A Functional Magnetic Resonance Imaging Study of Language Processing and Its Cognitive Correlates in Prematurely Born Children Pediatrics, December 1, 2002; 110(6): 1153 - 1162. [Abstract] [Full Text] [PDF] |
||||
![]() |
L J Abernethy, M Palaniappan, and R W I Cooke Quantitative magnetic resonance imaging of the brain in survivors of very low birth weight Arch. Dis. Child., October 1, 2002; 87(4): 279 - 283. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. S. Peterson, B. Vohr, L. H. Staib, C. J. Cannistraci, A. Dolberg, K. C. Schneider, K. H. Katz, M. Westerveld, S. Sparrow, A. W. Anderson, et al. Regional Brain Volume Abnormalities and Long-term Cognitive Outcome in Preterm Infants JAMA, October 18, 2000; 284(15): 1939 - 1947. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
| ARCH DIS CHILD | FETAL NEONATAL ED | ED PRACTICE |