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Department of Child
Health University of Liverpool
Royal Liverpool Children's Hospital (Alder
Hey) Liverpool L12 2AP
Correspondence to: Dr R Cooke.
Accepted 7
April 1999
AIM
To determine
whether neurological deficits are associated with structural anomalies
of the brain in very low birthweight (VLBW) infants with subsequent
learning disorders but without cerebral palsy, or whether other
factors, such as poor early growth, are responsible.
METHODSEighty seven
VLBW infants and eight term controls who had been examined at school
between the ages of 12 and 13 years, had cranial magnetic resonance
imaging (MRI) scans at 15-17 years of age.
RESULTSThirty seven
(42.5%) of the VLBW children had abnormalities reported on their scans
(two porencephaly, 28 periventricular leucomalacia, 24 ventricular
dilatation, and 15 thinning of the corpus callosum). No significant
differences in intelligence quotient, motor clumsiness, or frequency of
attention deficit / hyperactivity disorder were observed between those
children with MRI lesions and those with normal scans. Quantitative
measurements showed the VLBW infants had smaller brains, and a
relatively smaller corpus callosum compared with controls. No
association between brain measurements and school performance was
observed among the VLBW infants.
CONCLUSIONSThe
difficulties experienced by VLBW children at school are unlikely to be
the result of perinatal brain injury, but they might to be attributable
to the effects of poor postnatal growth.
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