Observational study of maternal anthropometry and fetal insulin
H Soltani-K, C Bruce, R B Fraser
University
Department of Obstetrics and Gynaecology
Northern General Hospital
Sheffield
Correspondence to: Dr H Soltani-K School of Nursing and Midwifery University of Sheffield Sheffield S10 2HL. Email: h.soltani{at}sheffield.ac.uk
Accepted 23 April 1999
AIMS
To examine the
relation between maternal body fat and fetal metabolism.
METHODSIn this
observational study, cord blood samples were collected from 60 infants
of healthy women for the measurement of insulin and C peptide
concentrations. Maternal weight, height, body mass index (BMI) and body
composition (skinfold thickness measurements and bioelectrical
impedance) were assessed at 13-15 weeks of gestation. Twenty five of
the volunteers agreed to have a 75 g oral glucose tolerance test at
28-31 weeks of gestation.
RESULTSPositive
correlations were observed with both cord insulin or C peptide
concentrations and maternal early pregnancy BMI (r=0.44, p=0.002 and
r=0.33, p=0.008, respectively). There was no significant correlation
between cord insulin or C peptide concentrations and birthweight or
birth weight centiles.
CONCLUSIONMaternal
BMI could be a predictor of fetal cord insulin concentration.
Keywords: maternal anthropometry; body composition; insulin; body mass index
© 1999 by Archives of Disease in Childhood
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