Erythrocyte glutathione S transferase as a marker of oxidative stress at birth
V M E Neefjesa, C T A Evelob, L G M Baarsb, C E Blancoa
a Department of
Paediatrics Academic Hospital Maastricht
PO Box 5800 6202 AZ
Maastricht The Netherlands, b Department of
Pharmacology (Toxicology section)
Correspondence to: Dr C E Blanco. Email:CBL{at}skin.azm.nl
Accepted 26 April 1999
AIMS
To determine the
level of oxidative stress and cell damage as a result of exposure to
O2 at birth.
METHODSUsing
glutathione S transferase (GST) as an indicator of oxidative stress,
GST activity in cord blood was compared with that in samples taken
three hours after birth. Twenty four prematurely born infants and eight
full term infants were studied. To test whether stronger effects occur
under less favourable conditions, the neonates were divided in three
groups: healthy premature; sick premature; and healthy full term infants.
RESULTSGST activity
three hours after birth was significantly decreased compared with that
at birth in all three groups tested. There were no significant
differences in the magnitude of this effect among the three groups.
CONCLUSIONSThese
results indicate that a sudden increase in oxygenation exposes the
neonate to oxidative stress. Measurement of GST activity might be
useful for the evaluation of protective treatment in trials considering
antioxidant strategies.
Keywords: glutathione S transferase; oxidative stress; birth; prematurity
© 1999 by Archives of Disease in Childhood
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