HFE gene mutation and transferrin saturation in very low birthweight infants
Rolf F Maiera, Heiko Wittb, Christoph Bührera, Eberhard Mönchc, Eckart Köttgenb
a Department of
Neonatology Charité Virchow Hospital
Humboldt University
D-13353 Berlin Germany, b Department
of Laboratory Medicine and Pathobiochemistry, c Department of General
Paediatrics
Correspondence to: Dr Heiko Witt. Email: heiko.witt{at}charite.de
Accepted 5 May 1999
AIM
To determine if
there is an association between high transferrin saturation and the
C282Y HFE gene mutation in very low birthweight (VLBW) infants.
METHODSOne hundred
and forty three VLBW infants receiving recombinant erythropoietin and 3 to 9 mg/kg/day of enteral iron were studied. Genomic DNA was extracted
from filter paper cards. The C282Y mutation was determined by
restriction fragment length polymorphism analysis.
RESULTSSix infants
were heterozygous for the mutation; none was homozygous. Ten infants
had a transferrin saturation above 80% at least once. No infant was
positive for both transferrin saturation above 80% and the mutation.
CONCLUSIONSThe data
strongly suggest that there is no association between high transferrin
saturation and the HFE gene mutation in VLBW infants during the first
weeks of life.
Keywords: transferrin saturation; HFE gene mutation
© 1999 by Archives of Disease in Childhood
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