Sodium potassium adenosine triphosphatase activity in preterm and term infants and its possible role in sodium homeostasis during maturation
T Bistritzera, M Berkovitcha, M J Rappoportb, S Evansc, S Arielid, M Goldberge, I Tavorie, M Aladjema
a Department
of Paediatrics Assaf Hroheh Medical Center
Zerifin 70300 Sackler
School of Medicine Tel Aviv University
Tel Aviv Israel, b Department of Internal Medicine, c Department of Biochemical Pathology, d Department of Obstetrics, e Department of Neonatology
Correspondence to: Dr Tzvy Bistritzer. Email: mberkovitch{at}asaf.health.gov.il
Accepted 25 May 1999
AIM
To investigate
sodium (NA+) potassium (K+) adenosine
triphosphatase (ATPase) activity in newborn infants at different
gestational ages, to elucidate the mechanism underlying poor renal
sodium conservation in preterm infants.
METHODSFifty three
healthy newborn infants, gestational age 30-42 weeks, were studied.
Umbilical cord red blood cell Na+ K+ATPase
activity, plasma renin activity, and plasma aldosterone activities were
measured in all of them. Red blood cell
Na+ K+ATPase activity was re-examined in eight
preterm infants, one and two weeks after birth. Total and ouabain
sensitive ATPase activity was measured spectrophotometrically using a
method that couples ATP hydrolysis with NADH oxidation.
RESULTSRed blood cell
Na+ K+ATPase activity was significantly lower
(p<0.01) in preterm babies with a gestational age below 35 weeks, compared with those with aged 35 weeks and above: 2.3 (0.8) and 6.7 (1.3) nmol NADH/minute/mg protein, respectively. There was no
correlation between gestational age,
Na+ K+ATPase, plasma renin activity and
aldosterone values either in the preterm or term babies. Two weeks
after birth, irrespective of gestational age, the enzyme activity of
the preterm babies increased to values similar to those observed in the
term neonates at birth.
CONCLUSIONThe
differences in sodium homeostasis between term and preterm babies are
modulated via changes in Na+ K+ATPase activity.
Keywords: Na+ K+ ATPase activity; sodium homeostasis
© 1999 by Archives of Disease in Childhood
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
Vasarhelyi, B., Tulassay, T., Ver, A., Dobos, M., Kocsis, I., Seri, I.
(2000). Developmental changes in erythrocyte Na+,K+-ATPase subunit abundance and enzyme activity in neonates. Arch. Dis. Child. Fetal Neonatal Ed.
83: 135F-138
[Abstract] [Full Text]
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in ADC Online
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
