Concentration of nitric oxide products in bronchoalveolar fluid obtained from infants who develop chronic lung disease of prematurity
Julian R Vyasa, Andrew E Curriea, David E G Shukerb, David J Fielda, Sailesh Kotechaa
a Department of Child
Health Centre for Mechanisms of Human Toxicity
University of Leicester
Leicester LE2 7LX, b MRC
Toxicology Unit University of Leicester
Correspondence to: Dr Sailesh Kotecha.
Accepted 23 April 1999
AIMS
To determine if
nitric oxide (NO) products (nitrate and nitrite) are increased in
bronchoalveolar lavage (BAL) fluid obtained from infants who develop
chronic lung disease of prematurity (CLD).
METHODSOne hundred
and thirty six serial bronchoalveolar lavages were performed on 37 ventilated infants (12 with CLD, 18 with respiratory distress syndrome
(RDS), and seven control infants) who did not receive inhaled NO.
RESULTSDuring the
first week of life nitrate concentration was between 25-31 µmol/l in
all three groups. Thereafter, the concentration of BAL fluid nitrate
decreased to 14 µmol/l and 5.5 µmol/l, respectively in the RDS and
control groups by 14 days of age. In contrast, nitrate in the CLD
infants remained constant until 28 days of age (31.3 µmol/l at day
14; p<0.05). In all BAL fluid samples the mean concentration of
nitrite was <1.2 µmol/l throughout the first 28 days with no
significant differences noted among the three groups.
CONCLUSIONThe similar
concentration of BAL fluid nitrate in all groups during the first week
of life suggest that NO may be important in the adaptation of the
pulmonary circulation after birth. However, persistence of nitrate in
the BAL fluid of infants with CLD during the second week may reflect
pulmonary maladaptation, or, more likely, persisting pulmonary inflammation.
Keywords: chronic lung disease of prematurity; nitric oxide; nitrate; bronchopulmonary dysplasia
© 1999 by Archives of Disease in Childhood
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
Williams, O, Bhat, R Y, Cheeseman, P, Rafferty, G F, Hannam, S, Greenough, A
(2004). Exhaled nitric oxide in chronically ventilated preterm infants. Arch. Dis. Child. Fetal Neonatal Ed.
89: F88-F89
[Abstract] [Full Text] -
Afshar, S., Gibson, L. L., Yuhanna, I. S., Sherman, T. S., Kerecman, J. D., Grubb, P. H., Yoder, B. A., McCurnin, D. C., Shaul, P. W.
(2003). Pulmonary NO synthase expression is attenuated in a fetal baboon model of chronic lung disease. Am. J. Physiol. Lung Cell. Mol. Physiol.
284: L749-L758
[Abstract] [Full Text]
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in ADC Online
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
-
Immunology (including allergy)
-
Pneumonia (infectious disease)
-
TB and other respiratory infections
-
Drugs: CNS (not psychiatric)
-
Child health
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
