Randomised controlled trial of patient triggered and conventional fast rate ventilation in neonatal respiratory distress syndrome
M W Beresford, N J Shaw, D Manning
Neonatal Unit,
Liverpool Women's Hospital,
Crown Street, Liverpool
L8 7SS
Correspondence to: Dr N J Shaw
Accepted 1 August 1999
AIM
To compare
patient triggered, with conventional fast rate, ventilation in a
randomised controlled trial using the incidence of chronic lung disease
as the primary outcome measure.
METHODSThree
hundred and eighty six preterm infants with birthweights from 1000 to
2000 g, and requiring ventilation for respiratory distress syndrome
within 24 hours of birth, were randomised to receive either
conventional or trigger ventilation with the SLE 2000 ventilator.
RESULTSThere
were no significant differences in the incidence of chronic lung
disease (28 day and 36 week definitions), death, pneumothorax, intraventricular haemorrhage, number of ventilator days, or length of
oxygen dependency between groups.
CONCLUSIONSPatient
triggered ventilation in preterm infants with respiratory distress
syndrome is feasible. No significant differences, when compared with
conventional fast rate ventilation in important medium and longer term
outcome measures, were evident.
Keywords: patient triggered ventilation; prematurity; respiratory distress syndrome
© 2000 by Archives of Disease in Childhood
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