Maternal insulin-like growth factor binding protein-1, body mass index, and fetal growth
Robert P Holmesa, J M P Hollyb, Peter W Soothilla
a Fetal Medicine
Research Unit, University of Bristol,
St Michael's Hospital,
Southwell Street,
Bristol BS2 8EG, UK, b Department of Surgery,
University of Bristol,
Bristol Royal Infirmary
Correspondence to: Professor P Soothill email: Peter.Soothill{at}bristol.ac.uk
Accepted 31
July 1999
AIM
To examine the
hypothesis that the maternal insulin-like growth factor system may
constrain fetal growth.
METHODSA prospective
observational study of maternal serum insulin-like growth factor
binding protein-1 (IGFBP-1) and fetal growth was undertaken in neonates
with birthweights below the 5th centile. They had been classified
either as having fetal growth restriction (FGR) due to placental
dysfunction (increased umbilical artery Doppler pulsatility index (PI);
n = 25) or as being small for gestational age (SGA; normal umbilical
artery PI, growth velocity and amniotic fluid; n = 27). Eighty nine
controls had normal birthweights (5th-95th centile), umbilical artery
PI, growth velocity, and amniotic fluid. IGFBP-1 was measured by radioimmunoassay.
RESULTSAmong the
controls, there was no significant correlation between IGFBP-1 and
birthweight after allowing for body mass index (BMI). Maternal BMI was
high in FGR and after adjusting for this, IGFBP-1 was increased (109 ng/ml) compared with SGA babies (69 ng/ml) and controls (57 ng/ml) and
correlated with the umbilical artery PI.
CONCLUSIONSMaternal
IGFBP-1 is probably not part of normal placental function. Its increase
in FGR could be the cause or consequence of impaired placental
perfusion, but high IGFBP-1 concentrations might further reduce the
availability of maternal IGF-I to the placenta. This could worsen
placental function and so adversely affect fetal growth.
|
Key messages
|
Keywords: insulin-like growth factor binding protein-1; growth restriction; umbilical artery; Doppler pulsatility index
© 2000 by Archives of Disease in Childhood
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
Troisi, R., Potischman, N., Hoover, R. N.
(2007). Exploring the Underlying Hormonal Mechanisms of Prenatal Risk Factors for Breast Cancer: A Review and Commentary. Cancer Epidemiol. Biomarkers Prev.
16: 1700-1712
[Abstract] [Full Text] -
Tisi, D. K., Emard, J. J., Koski, K. G.
(2004). Total Protein Concentration in Human Amniotic Fluid Is Negatively Associated with Infant Birth Weight. J. Nutr.
134: 1754-1758
[Abstract] [Full Text] -
Westwood, M., Gibson, J.M., Sooranna, S. R., Ward, S., Neilson, J. P., Bajoria, R.
(2001). Genes or placenta as modulator of fetal growth: evidence from the insulin-like growth factor axis in twins with discordant growth. Mol Hum Reprod
7: 387-395
[Abstract] [Full Text]
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in ADC Online
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
-
Immunology (including allergy)
-
Drugs: CNS (not psychiatric)
-
Pregnancy
-
Reproductive medicine
- Drugs: endocrine system
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
