Measurement of interleukin 10 in bronchoalveolar lavage from preterm ventilated infants
Janet R McColm, Ben J Stenson, Nienke Biermasz, Neil McIntosh
Child
Life and Health, Reproductive Medicine and Developmental Sciences,
University of Edinburgh, 20 Sylvan Place, Edinburgh EH9 1UW, UK
Correspondence to: Dr McColm
Accepted 4 November
1999
BACKGROUND
Interleukin
10 (IL-10) is a cytokine that downregulates inflammation, in part by
reducing the production of the proinflammatory cytokines IL-1
and
IL-8. It has been suggested that an inability to produce IL-10 might
predispose preterm infants to develop chronic lung disease.
AIMTo measure IL-10,
IL-1, and IL-8 in bronchoalveolar lavage fluid from ventilated
preterm infants in a prospective cohort study.
PATIENTS17
consecutive newborn infants 
29 weeks' gestational age (median,
25; 9 boys) who were ventilated from birth underwent daily bronchoalveolar lavage sampling.
RESULTS102 samples
were collected, of which 57 contained IL-10 in amounts that were
comparable with those found previously in ventilated term infants with
respiratory failure. Chronic lung disease developed in 9 of the 11 survivors and all 9 infants had produced IL-10. IL-1 and IL-8 were
detected in nearly all samples and were raised throughout the course of
sample collection.
CONCLUSIONIL-10 is
readily detectable in early bronchoalveolar lavage samples from
ventilated preterm infants, although it remains unclear whether this
cytokine has any influence on the development of chronic lung disease.
Keywords: inflammation; cytokines; bronchopulmonary dysplasia; chronic lung disease; very preterm infants
© 2000 by Archives of Disease in Childhood
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