A randomised control study of partial liquid ventilation after airway lavage with exogenous surfactant in a meconium aspiration syndrome animal model
Tomohiko Nakamura, Shigeyuki Matsuzawa, Masatoshi Sugiura, Masanori Tamura
Division of
Neonatology, Nagano Children's Hospital, 3100 Toyoshina, Nagano,
399-8288 Japan
Correspondence to: Dr Nakamura email: ngchnicu{at}avis.ne.jp
Accepted 14
September 1999
AIMS
To test the
hypothesis that lavage with exogenous surfactant before partial liquid
ventilation in meconium aspiration syndrome (MAS) would improve debris
removal, and therefore the effectiveness of partial liquid ventilation.
METHODS12 newborn
piglets were randomised into 4 groups, partial liquid ventilation or
gas ventilation, with and without surfactant lavage. Physiological and
blood gas data were compared between groups by analysis of variance.
RESULTSArterial
oxygen pressure (PaO2) was improved in the group treated
with surfactant lavage when compared with the group not receiving
surfactant. PaO2 in the group receiving surfactant lavage followed by partial liquid ventilation was further improved when compared with the group treated with surfactant lavage followed by gas
ventilation and the group receiving partial liquid ventilation alone.
CONCLUSIONThe
effectiveness of partial liquid ventilation in MAS might be enhanced by
pretreatment with exogenous surfactant bronchial lavage.
Keywords: meconium aspiration syndrome; partial liquid ventilation; exogenous surfactant
© 2000 by Archives of Disease in Childhood
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