Increased leptin concentration in preterm infants of pre-eclamptic mothers
Timo Hytinanttia, Heikki A Koistinenb, Veikko A Koivistob, Sirkka-Liisa Karonenc, Eeva-Marja Rutanend, Sture Anderssond
a Helsinki City
Maternity Hospital, Sofianlehdonkatu 5, SF-00610 Helsinki, Finland, b Department of Medicine,
Helsinki University Central Hospital, Helsinki, Finland, c Department of
Clinical Chemistry, Helsinki University Central Hospital, d Department
of Obstetrics and Gynaecology, Helsinki University Central Hospital
Correspondence to: Dr Hytinantti
Accepted 3 September
1999
AIM
To study the
effect of maternal pre-eclampsia on cord plasma leptin concentrations
in preterm infants.
METHODSLeptin
concentration was analysed in cord plasma of 74 preterm infants,
gestational age 24 to 32 weeks. Of these, 14 were born to pre-eclamptic
mothers, in 10 intrauterine growth retardation (IUGR) was present, and
59 had been exposed antenatally to corticosteroids.
RESULTSThe mean (SD)
concentration of cord plasma leptin was 1.31 (0.88) µg/l. A
significant correlation was found between leptin concentration and
gestational age (r = 0.336; p = 0.0037).
Leptin levels were higher in infants of pre-eclamptic mothers
(p = 0.0007), in those with IUGR (p = 0.0005), and in infants
exposed antenatally to corticosteroids (p = 0.02). In multiple
regression analysis, leptin was associated with gestational age and
maternal pre-eclampsia (both p < 0.05), but not with antenatal corticosteroids.
CONCLUSIONSIncreased
fetal leptin in maternal pre-eclampsia may reflect a physiological
adaptation to fetal stress such as hypoxia.
Keywords: leptin; preterm infants; pre-eclampsia; hypoxia
© 2000 by Archives of Disease in Childhood
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