Markers of collagen metabolism and insulin-like growth factor binding protein-1 in term infants
T Hytinanttia b, E-M Rutanenc, M Turpeinend, R Sorvad, S Anderssonb c
a Helsinki City
Maternity Hospital, Helsinki, Finland, b The Hospital for Children and Adolescents,
Helsinki, Finland, c Department of Obstetrics and Gynecology,
Helsinki University Central Hospital, Helsinki, Finland, d Department
of Allergology, Helsinki University Central Hospital
Correspondence to: Dr Hytinantti, Helsinki City Maternity Hospital, Sofianlehdonkatu 5, 00610 Helsinki, Finland
Accepted 22 October
1999
AIM
To study the
relation between fetal growth and markers of collagen metabolism and
insulin-like growth factor binding protein-1 (IGFBP-1) in term infants.
METHODSCord vein
plasma was obtained from 67 term infants of gestational age 37.1-41.7
weeks (39 appropriate for gestational age (AGA), 11 large for
gestational age (LGA; relative birth weight 
2.0 SD), and 17 small
for gestational age (SGA; relative birth weight 
2.0 SD)) for
analysis of markers of metabolism of collagen type I (PICP and ICTP)
and III (PIIINP) and of IGFBP-1.
RESULTSNegative
correlations existed between gestational age and PICP
(r = 0.294, p = 0.0158), ICTP
(r = 0.338, p = 0.0052), and PIIINP
(r = 0.432, p = 0.0003). These
correlations were also found in SGA infants (all p < 0.05). IGFBP-1
showed negative correlations with birth weight and relative birth
weight (r = 0.644, p = 0.0001, and
r = 0.693, p = 0.0001 respectively)
but not with gestational age (p>0.05).
CONCLUSIONSIn the
term fetus, collagen metabolism is primarily dependent on maturity and
not on intrauterine growth status, whereas IGFBP-1 reflects
intrauterine growth independently of maturity.
Keywords: collagen; growth status; insulin-like growth factor binding protein-1; fetus
© 2000 by Archives of Disease in Childhood
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