Arch. Dis. Child

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER


[Advanced]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this link to a friend
Right arrow Similar articles in ADC Online
Right arrow Similar articles in PubMed
Right arrow Add article to my folders
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Carnielli, V. P
Right arrow Articles by Zacchello, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Carnielli, V. P
Right arrow Articles by Zacchello, F.
Arch Dis Child Fetal Neonatal Ed 2000;83:F39-F43 ( July )

Metabolic and respiratory effects of theophylline in the preterm infant

Virgilio P Carnielli, Giovanna Verlato, Franca Benini, Katia Rossi, Monica Cavedagni, Marco Filippone, Eugenio Baraldi, Franco Zacchello

Dipartimento di Pediatria, Via Giustiniani 3, 35128 Padova, Italy

Correspondence to: Dr Carnielli email: carnielli{at}child.pedi.unipd.it

Accepted 17 December 1999

BACKGROUND---Methylxanthines are often administered to preterm infants for the treatment of apnoea.
AIMS---To study the effects of theophylline on energy metabolism, physical activity, and lung mechanics in preterm infants.
METHODS---Indirect calorimetry was performed for six hours before and after administration of a bolus of theophylline (5 mg/kg) in 18 preterm infants while physical activity was recorded with a video camera. Lung mechanics measurements were performed at baseline and 12 and 24 hours after theophylline treatment.
RESULTS---Theophylline increased mean (SEM) energy expenditure by 15 (5) kJ/kg/day and augmented carbohydrate utilisation from 6.8 to 8.0 g/kg/day, but fat oxidation was unchanged. After theophylline treatment, preterm infants had faster respiration, lower transcutaneous CO2, and improved static respiratory compliance without increased physical activity.
CONCLUSIONS---A bolus of 5 mg/kg theophylline increased energy expenditure independently of physical activity, increased carbohydrate utilisation, and improved respiratory compliance. The increased energy expenditure could be detrimental to the growth of the preterm infant.


Keywords: theophylline; preterm infant; calorimetry; energy metabolism; lung; apnoea

© 2000 by Archives of Disease in Childhood


This article has been cited by other articles:


Home page
 NEJMHome page
B. Schmidt, R. S. Roberts, P. Davis, L. W. Doyle, K. J. Barrington, A. Ohlsson, A. Solimano, W. Tin, and the Caffeine for Apnea of Prematurity Trial Group
Caffeine Therapy for Apnea of Prematurity
N. Engl. J. Med., May 18, 2006; 354(20): 2112 - 2121.
[Abstract] [Full Text] [PDF]

Home page
 Nutr Clin PractHome page
S. J. Carlson
Current Nutrition Management of Infants With Chronic Lung Disease
Nutr Clin Pract, December 1, 2004; 19(6): 581 - 586.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER
ARCH DIS CHILD FETAL NEONATAL ED ED PRACTICE
Terms and conditions relating to subscriptions purchased online  ¦  Website terms and conditions  ¦  Privacy policy
Copyright © 2000 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health