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Arch Dis Child Fetal Neonatal Ed 2000;83:F86-F90 ( September )

Randomised trial of iodine intake and thyroid status in preterm infants

Jenny Rogahna, Steven Ryanb, John Wellsd, Bill Fraserc, Christine Squirec, Nick Wildg, Adrian Hughesf, Laweh Amegaviee

a Neonatal Unit, Liverpool Women's Hospital, Liverpool, UK, b Royal Liverpool Children's NHS Trust, Alder Hey Hospital, Liverpool, c Department of Clinical Chemistry, Royal Liverpool University Hospital, Liverpool, d Cow and Gate Nutricia Limited, Trowbridge, Wiltshire, UK, e Paediatric Department, Whiston Hospital, Merseyside, UK, f Paediatric Department, Arrowe Park Hospital, Merseyside, g Paediatric Department, Warrington Hospital, Merseyside

Correspondence to: Dr Ryan, RLC NHS Trust, Alder Hey Hospital, Liverpool L12 2AP, UK email: Steve.Ryan{at}RLCH-TR.NWEST.NHS.UK

Accepted 28 April 2000

BACKGROUND---Low levels of circulating thyroid hormones have been associated with poorer general and neurodevelopmental outcome in preterm babies and it has been speculated that the association is causal. Low levels of circulating thyroid hormone have been reported after inadequate intake of iodine in preterm infants being fed milk formula.
AIM---To investigate whether increased iodine intake from supplemented preterm formula would improve thyroid hormone levels in preterm babies (this study) and hence improve neurodevelopmental status (planned subsequent study).
METHOD---A total of 121 preterm infants were entered into a randomised controlled trial of standard (68 µg/l) versus increased (272 µg/l) iodine in preterm formula.
RESULTS---The two groups were comparable at recruitment. No evidence of an effect of the intervention on thyroid hormone levels was seen up to 41 weeks after conception.
CONCLUSION---Calls for increased iodine content of preterm infant formulas are not justified by this study.


Key message

  • Increasing milk iodine content in line with the latest recommendations for preterm babies had no effect on thyroid hormone levels in the perinatal period




Keywords: premature; randomised controlled trial; iodine; thyroid function; milk formula

© 2000 by Archives of Disease in Childhood


This article has been cited by other articles:


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 Arch. Dis. Child. Fetal Neonatal Ed.Home page
M Ibrahim, G M. de Escobar, T J Visser, S Duran, H van Toor, J Strachan, F L R Williams, and R Hume
Iodine deficiency associated with parenteral nutrition in extreme preterm infants
Arch. Dis. Child. Fetal Neonatal Ed., January 1, 2003; 88(1): F56 - 57.
[Abstract] [Full Text] [PDF]


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