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Archives of Disease in Childhood - Fetal and Neonatal Edition 2001;84:F134-F135; doi:10.1136/fn.84.2.F134
Copyright © 2001 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health.
Arch Dis Child Fetal Neonatal Ed 2001;84:F134-F135 ( March )

Short report

Neonatal paroxetine withdrawal syndrome J A Stiskala, N Kulinb, G Korenb, T Hob, S Itob

a Division of Neonatology, Morristown Memorial Hospital, Morristown, New Jersey, USA, b Division of Clinical Pharmacology and Toxicology, Motherisk Program, Department of Pediatrics, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8

Correspondence to: Dr Ito ito{at}sickkids.on.ca

Accepted 31 October 2000

Four term neonates presented with symptoms such as jitteriness and necrotising enterocolitis after paroxetine exposure in utero.


Key messages

  • Paroxetine withdrawal syndrome was suspected in four neonates exposed to the drug in utero at maternal doses ranging from 20 to 120 mg/day
  • The symptoms and abnormalities included, but were not limited to, jitteriness, vomiting, irritability, hypoglycaemia, and necrotising enterocolitis
  • Close observation is warranted for neonates exposed to paroxetine in utero




Keywords: neonates; paroxetine; withdrawal; serotonin reuptake inhibitors; necrotising enterocolitis


© 2001 by Archives of Disease in Childhood

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  • ISBISTER, G. K, DAWSON, A., WHYTE, I. M, PRIOR, F. H, CLANCY, C., SMITH, A. J, STISKAL, J. A, ITO, S. (2001). Neonatal paroxetine withdrawal syndrome or actually serotonin syndrome?. Arch. Dis. Child. Fetal Neonatal Ed. 85: F145g-145 [Full Text]  

eLetters:

Read all eLetters

Neonatal paroxetine withdrawal syndrome or actually serotonin syndrome?
Geoffrey K Isbister
Fetal Neonatal Ed. Online, 24 Mar 2001 [Full text]
Neonatal paroxetine withdrawal syndrome or actually serotonin syndrome? - Authors' response
Joseph Stiskal
Fetal Neonatal Ed. Online, 12 Apr 2001 [Full text]

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