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Arch Dis Child Fetal Neonatal Ed 2001;84:F90-F91 ( March )

Brain specific proteins in posthaemorrhagic ventricular dilatation

A Whitelawa, L Rosengrenb, M Blennowc

a Division of Child Health, University of Bristol, Bristol, UK, b Department of Neurology, Sahlgrenska Hospital, Gothenburg, Sweden, c Department of Paediatrics, Huddinge Hospital, Huddinge, Sweden

Correspondence to: Professor Whitelaw, Division of Child Health, University of Bristol Medical School, Southmead Hospital, Bristol BS10 5NB, UK email: andrew.whitelaw{at}bristol.ac.uk

Accepted 21 January 2000

Median neurofilament and glial fibrillary acidic protein concentrations in the cerebrospinal fluid of 18 infants with posthaemorrhagic ventricular dilatation were 20-200 times higher than control values. S-100 protein in cerebrospinal fluid was four times higher than control values. Glial fibrillary acidic protein concentrations correlated with death or disability and with parenchymal lesions but not with shunt dependence.


Keywords: cerebrospinal fluid; glial fibrillary acidic protein; posthaemorrhagic ventricular dilatation; brain; neurodevelopment

© 2001 by Archives of Disease in Childhood


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