Time of closure of ductus venosus in term and preterm neonates
M Kondoa b, S Itoha, T Kunikatab, T Kusakaa, T Ozakib, K Isobea, S Onishia
a Department of
Pediatrics, Kagawa Medical University, Kagawa, Japan, b Division of Neonatal Unit, Ehime Perinatal
Center, Ehime Prefectural Central Hospital, Ehime, Japan
Correspondence to: Dr Onishi, Department of Pediatrics, Kagawa Medical University, 1750-1, Miki, Kitagun, Kagawa 761-0793, Japan sonishi{at}kms.ac.jp
Accepted 27 February
2001
AIM
To investigate the
relation between gestational age, birth weight, and antenatal
corticosteroid administration and the time of ductus venosus closure.
METHODSNinety eight
neonates of 30-41 weeks gestational age were studied by daily
ultrasonography until ductus venosus closure.
RESULTSIn neonates of
30-33 weeks gestational age, the ductus venosus closed at 6.0 (2.4)days (mean (SD)); in those of 34-36 weeks gestational age, it
closed at 6.1 (2.8) days; and in those of 37-41 weeks gestational age,
it closed at 4.2 (2.1) days. The effect of antenatal administration of
corticosteroids on the time of closure was also investigated in
neonates of 30-34 weeks gestational age. Closure occurred by 5.5 (2.4)
days in the group given corticosteroids compared with 7.5 (2.1) days in
the remainder.
CONCLUSIONSThe ductus
venosus closed sooner after birth in neonates of greater gestational
age or higher birth weight. Antenatal corticosteroid administration had
a significant effect in promoting closure.
Keywords: ductus venosus closure; antenatal corticosteroids; gestational age; birth weight
© 2001 by Archives of Disease in Childhood
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