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Arch Dis Child Fetal Neonatal Ed 2001;85:F57-F59 ( July )

Time of closure of ductus venosus in term and preterm neonates

M Kondoa b, S Itoha, T Kunikatab, T Kusakaa, T Ozakib, K Isobea, S Onishia

a Department of Pediatrics, Kagawa Medical University, Kagawa, Japan, b Division of Neonatal Unit, Ehime Perinatal Center, Ehime Prefectural Central Hospital, Ehime, Japan

Correspondence to: Dr Onishi, Department of Pediatrics, Kagawa Medical University, 1750-1, Miki, Kitagun, Kagawa 761-0793, Japan sonishi{at}kms.ac.jp

Accepted 27 February 2001

AIM---To investigate the relation between gestational age, birth weight, and antenatal corticosteroid administration and the time of ductus venosus closure.
METHODS---Ninety eight neonates of 30-41 weeks gestational age were studied by daily ultrasonography until ductus venosus closure.
RESULTS---In neonates of 30-33 weeks gestational age, the ductus venosus closed at 6.0 (2.4)days (mean (SD)); in those of 34-36 weeks gestational age, it closed at 6.1 (2.8) days; and in those of 37-41 weeks gestational age, it closed at 4.2 (2.1) days. The effect of antenatal administration of corticosteroids on the time of closure was also investigated in neonates of 30-34 weeks gestational age. Closure occurred by 5.5 (2.4) days in the group given corticosteroids compared with 7.5 (2.1) days in the remainder.
CONCLUSIONS---The ductus venosus closed sooner after birth in neonates of greater gestational age or higher birth weight. Antenatal corticosteroid administration had a significant effect in promoting closure.


Keywords: ductus venosus closure; antenatal corticosteroids; gestational age; birth weight

© 2001 by Archives of Disease in Childhood


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