Arch. Dis. Child

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER
[Advanced]

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this link to a friend
Right arrow Similar articles in ADC Online
Right arrow Similar articles in PubMed
Right arrow Add article to my folders
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mazzella, M
Right arrow Articles by Serra, G
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mazzella, M
Right arrow Articles by Serra, G
Arch Dis Child Fetal Neonatal Ed 2001;85:F86-F90 ( September )

A randomised control study comparing the Infant Flow Driver with nasal continuous positive airway pressure in preterm infants

M Mazzellaa, C Bellinia, M G Calevob, F Camponea, D Massoccoa, P Mezzanoa, E Zullinoa, F Scopesia, C Arionia, W Bonaccia, G Serraa

a Department of Pediatrics, Neonatal Intensive Care Unit, G Gaslini Institute, University of Genova, Genova, Italy, b Service of Biostatistics and Epidemiology, G Gaslini Institute

Correspondence to: Dr Mazzella, Department of Pediatrics, Neonatal Intensive Care Unit, G Gaslini Institute, University of Genova, Largo Gerolamo Gaslini 5, 16148 Genova, Italy massimomazzella{at}ospedale-gaslini.ge.it

Accepted 3 April 2001

OBJECTIVE---To compare the effectiveness of the Infant Flow Driver (IFD) with single prong nasal continuous positive airway pressure (nCPAP) in preterm neonates affected by respiratory distress syndrome.
DESIGN---Randomised controlled study.
PATIENTS---Between September 1997 and March 1999, 36 preterm infants who were eligible for CPAP treatment were randomly selected for either nCPAP or IFD and studied prospectively for changes in oxygen requirement and/or respiratory rate. The requirement for mechanical ventilation, complications of treatment, and effects on mid-term outcome were also evaluated.
RESULTS---Use of the IFD had a significantly beneficial effect on both oxygen requirement and respiratory rate (p < 0.0001) when compared with nCPAP. Moreover, O2 requirement and respiratory rate were significantly decreased by four hours (p < 0.001 and p < 0.03 respectively). The probability of remaining supplementary oxygen free over the first 48 hours of treatment was significantly higher in patients treated with the IFD than with nCPAP (p < 0.02). IFD treated patients had a higher success (weaning) rate (94% v 72 %) and shorter duration of treatment (49.3 (31) v 56 (29.7) hours respectively; mean (SD)), although the difference was not significant.
CONCLUSIONS---IFD appears to be a feasible device for managing respiratory distress syndrome in preterm infants, and benefits may be had with regard to oxygen requirement and respiratory rate when compared with nCPAP. The trend towards reduced requirement for mechanical ventilation, shorter clinical recovery time, and shorter duration of treatment requires further evaluation in a multicentre randomised clinical trial.


Keywords: Infant Flow Driver; continuous positive airway pressure; preterm; respiratory distress syndrome


© 2001 by Archives of Disease in Childhood



This article has been cited by other articles:


Home page
Arch. Dis. Child. Fetal Neonatal Ed.Home page
A A Hutchison and S Bignall
Non-invasive positive pressure ventilation in the preterm neonate: reducing endotrauma and the incidence of bronchopulmonary dysplasia
Arch. Dis. Child. Fetal Neonatal Ed., January 1, 2008; 93(1): F64 - F68.
[Full Text] [PDF]


Home page
Arch. Dis. Child. Fetal Neonatal Ed.Home page
R K Bomont and I U Cheema
Use of nasal continuous positive airway pressure during neonatal transfers
Arch. Dis. Child. Fetal Neonatal Ed., March 1, 2006; 91(2): F85 - F89.
[Abstract] [Full Text] [PDF]


Home page
PediatricsHome page
B. M. Stefanescu, W. P. Murphy, B. J. Hansell, M. Fuloria, T. M. Morgan, and J. L. Aschner
A Randomized, Controlled Trial Comparing Two Different Continuous Positive Airway Pressure Systems for the Successful Extubation of Extremely Low Birth Weight Infants
Pediatrics, November 1, 2003; 112(5): 1031 - 1038.
[Abstract] [Full Text] [PDF]


Home page
Arch. Dis. Child. Fetal Neonatal Ed.Home page
A G De Paoli, C Morley, and P G Davis
Nasal CPAP for neonates: what do we know in 2003?
Arch. Dis. Child. Fetal Neonatal Ed., May 1, 2003; 88(3): F168 - F172.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER
ARCH DIS CHILD FETAL NEONATAL ED ED PRACTICE
Terms and conditions relating to subscriptions purchased online  ¦  Website terms and conditions  ¦  Privacy policy
Copyright © 2001 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health