Genetic determinants of bone mineral content in premature infants
M C Backströma, A Mahonenb, M Ala-Houhalac, H Sievänend, P Mäenpääb, A M Koivistoe, A Olkkub, R Mäkic, M Mäkif
a Department of
Paediatrics, Vasa Central Hospital, Sandviksgatan 1-3, FIN-65110 Vasa,
Finland, b Department of
Biochemistry, University of Kuopio, PO Box 1627, FIN-70211 Kuopio,
Finland, c Department of Paediatrics, Tampere
University Hospital, PO Box 2000, FIN-33521 Tampere, Finland, d Bone
Research Group, UKK Institute, PO Box 30, FIN-33501 Tampere, e Tampere School of Public Health,
University of Tampere, f Department of Paediatrics, Medical School,
University of Tampere
Correspondence to: Dr Backström, Karlebyvägen 1457, FIN-66530 Kvevlax, Finland maria.backstrom{at}pp1.inet.fi
Accepted 14 August
2001
Genetic determinants of bone mineral content in prematurely
born children at 3 months and 9-11 years of age were studied. The
findings suggest that multiple genes are involved in the regulation of
site specific bone mass accumulation during childhood.
Keywords: bone mineral status; collagen; insulin-like growth factor I; oestrogen; vitamin D receptor
© 2001 by Archives of Disease in Childhood
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