ORIGINAL ARTICLE

Postnatal changes in maternal and neonatal plasma antioxidant vitamins and the influence of smoking

S Bolisetty¹, D Naidoo², K Lui², T H H G Koh¹, D Watson¹, R Montgomery¹ and J Whitehall¹

¹ Kirwan Hospital For Women, Townsville, Queensland, Australia
² University of New South Wales, Sydney, NSW, Australia

Correspondence to:
Correspondence to:
Dr Bolisetty, Alice Springs Hospital, PO Box 2234, Alice Springs, NT 0871, Australia;
srinib75{at}hotmail.com

Objective: To study the postnatal changes in the plasma concentrations of fat soluble antioxidant vitamins and malondialdehyde (MDA) in mothers and their newborns and their relation to smoking.

Design: Prospective cohort study.

Setting: Tertiary perinatal centre.

Subjects: Eighteen non-smoking and 14 smoking mothers and 33 infants.

Main outcome measures: Plasma concentrations of vitamins E, A, and ß-carotene and MDA were measured in mothers and infants at delivery and on day 4 post partum.

Results: Neonatal plasma levels of vitamins E, A, and ß-carotene were significantly lower than maternal levels both at delivery and on day 4 in both groups. There was a significant postnatal increase in plasma vitamin E levels in smoking mothers and neonates of both groups. A significant postnatal increase in maternal, but not neonatal, plasma vitamin A was noted in both groups. Cord plasma vitamin E levels were significantly lower in infants of smoking mothers (mean 4.7 v 6.5 µmol/l, p = 0.041). Plasma MDA was paradoxically lower in smoking mothers at delivery (3.19 v 4.01 µmol/l, p = 0.03) and on day 4 (1.37 v 3.29 µmol/l , p = 0.005) and in infants of the smoking group on day 4 (2.18 v 3.12 µmol/l, p = 0.014). Also, there was a significant postnatal fall in plasma MDA levels on day 4 in mothers and infants in the smoking group.

Conclusions: The postnatal changes in plasma vitamin E were more pronounced in the smoking group. The postnatal changes in plasma vitamins A and ß-carotene were similar in both groups. The rapid decline in plasma MDA in smoking mothers and their infants suggests withdrawal of oxidative stress from smoking around delivery. This coincided with the increase in plasma vitamin E.

Keywords: antioxidants; smoking; vitamins; pregnancy

Abbreviations: MDA, malondialdehyde

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Ermis, B., Ors, R., Yildirim, A., Tastekin, A., Kardas, F., Akcay, F. (2004). Influence of Smoking on Maternal and Neonatal Serum Malondialdehyde, Superoxide Dismutase, and Glutathione Peroxidase Levels. Annals of Clinical & Laboratory Science 34: 405-409 [Abstract] [Full Text]