| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
|
|
|
|
|||||||||||||
|
|
|||||||||||||||
ORIGINAL ARTICLE |
1 Division of Newborn Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA
2 Department of Neurology, Children's Hospital Boston, Harvard Medical School, Boston, USA
3 Department of Radiology, Children's Hospital Boston
4 Department of Radiology, Christchurch Hospital, University of Otago, New Zealand
5 Department of Paediatrics, Christchurch Hospital
6 Christchurch School of Medicine, Christchurch, New Zealand
Correspondence to:
Correspondence to:
Dr Inder, Murdoch Childrens Research Institute and Howard Florey Institute, Royal Childrens Hospital, Flemington Rd, Parkville, Victoria 3052, Australia;
indert{at}cryptic.rch.unimelb.edu.au
Objective: To investigate the natural history and predictors of outcome of posthaemorrhagic ventriculomegaly in the very low birthweight (VLBW) infant.
Methods: All VLBW infants admitted between September 1994 and September 1997 to the neonatal intensive care units of Brigham and Women's Hospital (Boston), Children's Hospital (Boston), and Christchurch Women's Hospital (New Zealand) with germinal matrix intraventricular haemorrhage (IVH) were identified. All charts and ultrasound scans were reviewed to define the natural history and perinatal and/or postnatal factors of value in prediction of the course of posthaemorrhagic ventriculomegaly. Progressive ventricular dilatation (PVD) was defined from the results of serial cranial ultrasound scans.
Results: A total of 248 VLBW infants had evidence of IVH (22% of all VLBW infants, mean (SD) gestational age 26.8 (2.6) weeks). A quarter of the infants exhibited PVD. Spontaneous arrest of PVD occurred without treatment in 38% of infants with PVD. Of the remaining 62% with persistent PVD, 48% received non-surgical treatment only (pharmacological and/or drainage of cerebrospinal fluid by serial lumbar punctures), 34% received surgical treatment with insertion of a ventriculoperitoneal reservoir and/or shunt, and 18% died. The development of PVD after IVH and adverse short term outcome, such as the requirement for surgery, were predicted most strongly by the severity of IVH.
Conclusions: These data reflect the natural history of PVD in the 1990s and show that, despite a slight reduction in its overall incidence, there appears to be a more aggressive course, with appreciable mortality and morbidity in the extremely premature infant. The major predictor of adverse short term outcome, defined as death or need for surgical intervention, was the severity of IVH. These findings may be valuable for the management of very small premature infants.
Keywords: intraventricular haemorrhage; posthaemorrhagic progressive ventricular dilatation; ventriculoperitoneal shunt; mortality
Abbreviations: IVH, intraventricular haemorrhage; VLBW, very low birthweight; PVD, progressive ventricular dilatation; VP, ventriculoperitoneal
Relevant Article
Arch. Dis. Child. Fetal Neonatal Ed. 2002 87: F2.
This article has been cited by other articles:
|
|
 |
|
  J Dudink, M Lequin, N Weisglas-Kuperus, N Conneman, J B van Goudoever, and P Govaert Venous subtypes of preterm periventricular haemorrhagic infarction Arch. Dis. Child. Fetal Neonatal Ed., May 1, 2008; 93(3): F201 - F206. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Kok, L. Prick, E. Merckel, Y. Everhard, G. J.Q. Verkerk, and S. A. Scherjon Visual Function at 11 Years of Age in Preterm-Born Children With and Without Fetal Brain Sparing Pediatrics, June 1, 2007; 119(6): e1342 - e1350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Whitelaw, D. Evans, M. Carter, M. Thoresen, J. Wroblewska, M. Mandera, J. Swietlinski, J. Simpson, C. Hajivassiliou, L. P. Hunt, et al. Randomized Clinical Trial of Prevention of Hydrocephalus After Intraventricular Hemorrhage in Preterm Infants: Brain-Washing Versus Tapping Fluid Pediatrics, May 1, 2007; 119(5): e1071 - e1078. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A J Brouwer, F Groenendaal, A van den Hoogen, M Verboon-Maciolek, P Hanlo, K J Rademaker, and L S de Vries Incidence of infections of ventricular reservoirs in the treatment of post-haemorrhagic ventricular dilatation: a retrospective study (1992-2003) Arch. Dis. Child. Fetal Neonatal Ed., January 1, 2007; 92(1): F41 - F43. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Bassan, C. B. Benson, C. Limperopoulos, H. A. Feldman, S. A. Ringer, E. Veracruz, J. E. Stewart, J. S. Soul, D. N. DiSalvo, J. J. Volpe, et al. Ultrasonographic features and severity scoring of periventricular hemorrhagic infarction in relation to risk factors and outcome. Pediatrics, June 1, 2006; 117(6): 2111 - 2118. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Nishimaki, Y. Iwasaki, and H. Akamatsu Cerebral Blood Flow Velocity Before and After Cerebrospinal Fluid Drainage in Infants With Posthemorrhagic Hydrocephalus J. Ultrasound Med., October 1, 2004; 23(10): 1315 - 1319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Heep, D Behrendt, P Nitsch, R Fimmers, P Bartmann, and J Dembinski Increased serum levels of interleukin 6 are associated with severe intraventricular haemorrhage in extremely premature infants Arch. Dis. Child. Fetal Neonatal Ed., November 1, 2003; 88(6): F501 - 504. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L T Weissman, P J Marro, D L Kessler, D B Sobel, D L Morrow, S Boggs, and W C Allan Progressive ventricular dilatation (PVD) over the past 22 years Arch. Dis. Child. Fetal Neonatal Ed., May 1, 2003; 88(3): F257 - F257. [Full Text] [PDF]
|
|
|
|
|
|
G Naulaers, G Morren, S Van Huffel, P Casaer, and H Devlieger Cerebral tissue oxygenation index in very premature infants Arch. Dis. Child. Fetal Neonatal Ed., November 1, 2002; 87(3): F189 - 192. [Abstract] [Full Text] [PDF]
|
|
Read all eLetters
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
| ARCH DIS CHILD | FETAL NEONATAL ED | ED PRACTICE |
