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Archives of Disease in Childhood - Fetal and Neonatal Edition 2002;87:F212-F213; doi:10.1136/fn.87.3.F212
Copyright © 2002 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health.
Archives of Disease in Childhood Fetal and Neonatal Edition 2002;87:F212
© 2002 Archives of Disease in Childhood Fetal and Neonatal Edition

SHORT REPORT

Endothelin 1 concentrations in infants with meconium stained amniotic fluid

S Yigit1, G Tekinalp1, O Oran1, M Yurdakok1, D Aliefendioglu2 and A Gurgey3

1 Hacettepe University Hospital, Department of Pediatrics, Division of Neonatology
2 Social Security Hospital, Ankara
3 Hacettepe University Hospital, Department of Pediatrics, Division of Haematology

Correspondence to:
Correspondence to:
Dr S Yigit, Ziraat Mühendisleri Sitesi 3/21 Çankaya 06550, Ankara, Turkey;
Suleyigit{at}turk.net

ABSTRACT

Plasma endothelin 1 concentrations were determined in infants with meconium stained amniotic fluid. Plasma endothelin 1 concentration in the study group (5.23 pg/ml) was statistically higher than that in the control group (1.12 pg/ml). Cord blood pH and base excess values were significantly lower in infants with meconium stained amniotic fluid when compared with the control group. There was no correlation between endothelin 1 concentrations and pH or base excess values. Results suggest that meconium passage is not a physiological event, even if meconium stained infants appear to be clinically healthy.

Keywords: meconium stained amniotic fluid; endothelin-1, meconium aspiration syndrome; newborn

Abbreviations: MAS, meconium aspiration syndrome; MSAF, meconium stained amniotic fluid


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